A2ML1 protein (Pongo abelii) - STRING interaction network

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Score

A2ML1

A2ML1 isoform 1. (1277 aa)

Predicted Functional Partners:

CCDC92B

0.721

FBXL21

0.677

CBX8

0.626

DPY19L2

0.600

CBX4

0.560

PHC2

0.543

RNF2

0.535

CR201_G0021544

0.535

RING1

0.535

BMI1

0.525

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A2ML1	BMI1	ENSPPYP00000004841	ENSPPYP00000002492	A2ML1 isoform 1.	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...]	0.525
A2ML1	CBX4	ENSPPYP00000004841	ENSPPYP00000009774	A2ML1 isoform 1.	CBX4 isoform 2.	0.560
A2ML1	CBX8	ENSPPYP00000004841	ENSPPYP00000024136	A2ML1 isoform 1.	CBX8 isoform 1.	0.626
A2ML1	CCDC92B	ENSPPYP00000004841	ENSPPYP00000024556	A2ML1 isoform 1.	Coiled-coil domain-containing protein 92.	0.721
A2ML1	CR201_G0021544	ENSPPYP00000004841	ENSPPYP00000009773	A2ML1 isoform 1.	CBX2 isoform 1.	0.535
A2ML1	DPY19L2	ENSPPYP00000004841	ENSPPYP00000019776	A2ML1 isoform 1.	DPY19L2 isoform 3.	0.600
A2ML1	FBXL21	ENSPPYP00000004841	ENSPPYP00000017673	A2ML1 isoform 1.	F-box and leucine-rich repeat protein 21.	0.677
A2ML1	PHC2	ENSPPYP00000004841	ENSPPYP00000001815	A2ML1 isoform 1.	PHC2 isoform 4.	0.543
A2ML1	RING1	ENSPPYP00000004841	ENSPPYP00000019327	A2ML1 isoform 1.	Ring finger protein 1.	0.535
A2ML1	RNF2	ENSPPYP00000004841	ENSPPYP00000000473	A2ML1 isoform 1.	E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...]	0.535
BMI1	A2ML1	ENSPPYP00000002492	ENSPPYP00000004841	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...]	A2ML1 isoform 1.	0.525
BMI1	CBX4	ENSPPYP00000002492	ENSPPYP00000009774	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...]	CBX4 isoform 2.	0.996
BMI1	CBX8	ENSPPYP00000002492	ENSPPYP00000024136	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...]	CBX8 isoform 1.	0.996
BMI1	CR201_G0021544	ENSPPYP00000002492	ENSPPYP00000009773	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...]	CBX2 isoform 1.	0.817
BMI1	PHC2	ENSPPYP00000002492	ENSPPYP00000001815	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...]	PHC2 isoform 4.	0.838
BMI1	RING1	ENSPPYP00000002492	ENSPPYP00000019327	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...]	Ring finger protein 1.	0.996
BMI1	RNF2	ENSPPYP00000002492	ENSPPYP00000000473	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...]	E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...]	0.998
CBX4	A2ML1	ENSPPYP00000009774	ENSPPYP00000004841	CBX4 isoform 2.	A2ML1 isoform 1.	0.560
CBX4	BMI1	ENSPPYP00000009774	ENSPPYP00000002492	CBX4 isoform 2.	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...]	0.996
CBX4	CBX8	ENSPPYP00000009774	ENSPPYP00000024136	CBX4 isoform 2.	CBX8 isoform 1.	0.994