| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BHMT | DHRS4 | ENSPPYP00000017424 | ENSPPYP00000006452 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | 0.419 |
| BHMT | PLBD1 | ENSPPYP00000017424 | ENSPPYP00000004932 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Phospholipase B-like; Putative phospholipase. | 0.616 |
| C4BPB | PLBD1 | ENSPPYP00000000286 | ENSPPYP00000004932 | Complement component 4 binding protein beta. | Phospholipase B-like; Putative phospholipase. | 0.530 |
| C4BPB | SPHKAP | ENSPPYP00000000286 | ENSPPYP00000014806 | Complement component 4 binding protein beta. | SPHKAP isoform 1. | 0.627 |
| DHRS4 | BHMT | ENSPPYP00000006452 | ENSPPYP00000017424 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | 0.419 |
| DHRS4 | PLBD1 | ENSPPYP00000006452 | ENSPPYP00000004932 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | Phospholipase B-like; Putative phospholipase. | 0.572 |
| GRAP2 | JAKMIP2 | ENSPPYP00000013217 | ENSPPYP00000017806 | GRB2 related adaptor protein 2. | JAKMIP2 isoform 2. | 0.728 |
| GRAP2 | PLBD1 | ENSPPYP00000013217 | ENSPPYP00000004932 | GRB2 related adaptor protein 2. | Phospholipase B-like; Putative phospholipase. | 0.728 |
| GRAP2 | ZNF831 | ENSPPYP00000013217 | ENSPPYP00000012494 | GRB2 related adaptor protein 2. | ZNF831 isoform 1. | 0.730 |
| JAKMIP2 | GRAP2 | ENSPPYP00000017806 | ENSPPYP00000013217 | JAKMIP2 isoform 2. | GRB2 related adaptor protein 2. | 0.728 |
| JAKMIP2 | PLBD1 | ENSPPYP00000017806 | ENSPPYP00000004932 | JAKMIP2 isoform 2. | Phospholipase B-like; Putative phospholipase. | 0.656 |
| JAKMIP2 | ZNF831 | ENSPPYP00000017806 | ENSPPYP00000012494 | JAKMIP2 isoform 2. | ZNF831 isoform 1. | 0.635 |
| PLA2G4A | PLBD1 | ENSPPYP00000000461 | ENSPPYP00000004932 | Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). | Phospholipase B-like; Putative phospholipase. | 0.590 |
| PLBD1 | BHMT | ENSPPYP00000004932 | ENSPPYP00000017424 | Phospholipase B-like; Putative phospholipase. | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | 0.616 |
| PLBD1 | C4BPB | ENSPPYP00000004932 | ENSPPYP00000000286 | Phospholipase B-like; Putative phospholipase. | Complement component 4 binding protein beta. | 0.530 |
| PLBD1 | DHRS4 | ENSPPYP00000004932 | ENSPPYP00000006452 | Phospholipase B-like; Putative phospholipase. | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | 0.572 |
| PLBD1 | GRAP2 | ENSPPYP00000004932 | ENSPPYP00000013217 | Phospholipase B-like; Putative phospholipase. | GRB2 related adaptor protein 2. | 0.728 |
| PLBD1 | JAKMIP2 | ENSPPYP00000004932 | ENSPPYP00000017806 | Phospholipase B-like; Putative phospholipase. | JAKMIP2 isoform 2. | 0.656 |
| PLBD1 | PLA2G4A | ENSPPYP00000004932 | ENSPPYP00000000461 | Phospholipase B-like; Putative phospholipase. | Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). | 0.590 |
| PLBD1 | SNAP29 | ENSPPYP00000004932 | ENSPPYP00000013412 | Phospholipase B-like; Putative phospholipase. | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. | 0.568 |
