| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARNTL2 | CIPC | ENSPPYP00000005000 | ENSPPYP00000006843 | Aryl hydrocarbon receptor nuclear translocator like 2. | CLOCK-interacting pacemaker; Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock. | 0.781 |
| ARNTL2 | CLOCK | ENSPPYP00000005000 | ENSPPYP00000016487 | Aryl hydrocarbon receptor nuclear translocator like 2. | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | 0.996 |
| ARNTL2 | CRY1 | ENSPPYP00000005000 | ENSPPYP00000005604 | Aryl hydrocarbon receptor nuclear translocator like 2. | Cryptochrome circadian regulator 1. | 0.824 |
| ARNTL2 | CRY2 | ENSPPYP00000005000 | ENSPPYP00000003822 | Aryl hydrocarbon receptor nuclear translocator like 2. | Cryptochrome circadian regulator 2. | 0.827 |
| ARNTL2 | CSNK1D | ENSPPYP00000005000 | ENSPPYP00000009846 | Aryl hydrocarbon receptor nuclear translocator like 2. | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | 0.749 |
| ARNTL2 | LOC100447547 | ENSPPYP00000005000 | ENSPPYP00000013183 | Aryl hydrocarbon receptor nuclear translocator like 2. | T0085674 isoform 1; Belongs to the protein kinase superfamily. | 0.735 |
| ARNTL2 | NPAS2 | ENSPPYP00000005000 | ENSPPYP00000013492 | Aryl hydrocarbon receptor nuclear translocator like 2. | NPAS2 isoform 1. | 0.978 |
| ARNTL2 | NPAS4 | ENSPPYP00000005000 | ENSPPYP00000003503 | Aryl hydrocarbon receptor nuclear translocator like 2. | Neuronal PAS domain protein 4. | 0.785 |
| ARNTL2 | PASD1 | ENSPPYP00000005000 | ENSPPYP00000023306 | Aryl hydrocarbon receptor nuclear translocator like 2. | PASD1 isoform 1. | 0.729 |
| ARNTL2 | PER2 | ENSPPYP00000005000 | ENSPPYP00000014901 | Aryl hydrocarbon receptor nuclear translocator like 2. | PER2 isoform 2. | 0.762 |
| CIPC | ARNTL2 | ENSPPYP00000006843 | ENSPPYP00000005000 | CLOCK-interacting pacemaker; Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock. | Aryl hydrocarbon receptor nuclear translocator like 2. | 0.781 |
| CIPC | CLOCK | ENSPPYP00000006843 | ENSPPYP00000016487 | CLOCK-interacting pacemaker; Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock. | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | 0.876 |
| CIPC | NPAS2 | ENSPPYP00000006843 | ENSPPYP00000013492 | CLOCK-interacting pacemaker; Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock. | NPAS2 isoform 1. | 0.614 |
| CIPC | PASD1 | ENSPPYP00000006843 | ENSPPYP00000023306 | CLOCK-interacting pacemaker; Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock. | PASD1 isoform 1. | 0.494 |
| CLOCK | ARNTL2 | ENSPPYP00000016487 | ENSPPYP00000005000 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | Aryl hydrocarbon receptor nuclear translocator like 2. | 0.996 |
| CLOCK | CIPC | ENSPPYP00000016487 | ENSPPYP00000006843 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | CLOCK-interacting pacemaker; Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock. | 0.876 |
| CLOCK | CRY1 | ENSPPYP00000016487 | ENSPPYP00000005604 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | Cryptochrome circadian regulator 1. | 0.996 |
| CLOCK | CRY2 | ENSPPYP00000016487 | ENSPPYP00000003822 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | Cryptochrome circadian regulator 2. | 0.996 |
| CLOCK | CSNK1D | ENSPPYP00000016487 | ENSPPYP00000009846 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | 0.975 |
| CLOCK | LOC100447547 | ENSPPYP00000016487 | ENSPPYP00000013183 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] | T0085674 isoform 1; Belongs to the protein kinase superfamily. | 0.976 |