TNS2 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	ITSN2	ENSPPYP00000008532	ENSPPYP00000014069	BCAR1 isoform 1.	ITSN2 isoform 3.	0.618
BCAR1	PTK2	ENSPPYP00000008532	ENSPPYP00000021213	BCAR1 isoform 1.	PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.999
BCAR1	PTK2B	ENSPPYP00000008532	ENSPPYP00000020691	BCAR1 isoform 1.	PTK2B isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.995
BCAR1	TNS2	ENSPPYP00000008532	ENSPPYP00000005206	BCAR1 isoform 1.	TNS2 isoform 7.	0.573
ERBB2	ERBB3	ENSPPYP00000009527	ENSPPYP00000005288	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	0.997
ERBB2	HGF	ENSPPYP00000009527	ENSPPYP00000020015	Receptor protein-tyrosine kinase.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.763
ERBB2	ITSN2	ENSPPYP00000009527	ENSPPYP00000014069	Receptor protein-tyrosine kinase.	ITSN2 isoform 3.	0.773
ERBB2	MET	ENSPPYP00000009527	ENSPPYP00000020106	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.884
ERBB2	MST1R	ENSPPYP00000009527	ENSPPYP00000015506	Receptor protein-tyrosine kinase.	MST1R isoform 1.	0.788
ERBB2	PTK2	ENSPPYP00000009527	ENSPPYP00000021213	Receptor protein-tyrosine kinase.	PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.984
ERBB2	PTK2B	ENSPPYP00000009527	ENSPPYP00000020691	Receptor protein-tyrosine kinase.	PTK2B isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.758
ERBB2	TNS2	ENSPPYP00000009527	ENSPPYP00000005206	Receptor protein-tyrosine kinase.	TNS2 isoform 7.	0.541
ERBB3	ERBB2	ENSPPYP00000005288	ENSPPYP00000009527	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	Receptor protein-tyrosine kinase.	0.997
ERBB3	HGF	ENSPPYP00000005288	ENSPPYP00000020015	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.925
ERBB3	ITSN2	ENSPPYP00000005288	ENSPPYP00000014069	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	ITSN2 isoform 3.	0.773
ERBB3	MET	ENSPPYP00000005288	ENSPPYP00000020106	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.972
ERBB3	MST1R	ENSPPYP00000005288	ENSPPYP00000015506	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	MST1R isoform 1.	0.681
ERBB3	PTK2	ENSPPYP00000005288	ENSPPYP00000021213	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.502
ERBB3	PTK2B	ENSPPYP00000005288	ENSPPYP00000020691	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	PTK2B isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.502
ERBB3	TNS2	ENSPPYP00000005288	ENSPPYP00000005206	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	TNS2 isoform 7.	0.541