MAP3K12 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLK1	MAP3K12	ENSPPYP00000006986	ENSPPYP00000005225	Delta like non-canonical Notch ligand 1.	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	0.498
FRA10AC1	MAP3K12	ENSPPYP00000002891	ENSPPYP00000005225	FRA10AC1 isoform 5.	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	0.544
MAP2K7	MAP3K12	ENSPPYP00000010648	ENSPPYP00000005225	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	0.935
MAP2K7	MAP3K13	ENSPPYP00000010648	ENSPPYP00000016066	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity).	0.935
MAP2K7	MAPK8IP1	ENSPPYP00000010648	ENSPPYP00000003821	Mitogen-activated protein kinase kinase 7.	MAPK8IP1 isoform 1.	0.985
MAP3K12	DLK1	ENSPPYP00000005225	ENSPPYP00000006986	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	Delta like non-canonical Notch ligand 1.	0.498
MAP3K12	FRA10AC1	ENSPPYP00000005225	ENSPPYP00000002891	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	FRA10AC1 isoform 5.	0.544
MAP3K12	MAP2K7	ENSPPYP00000005225	ENSPPYP00000010648	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	Mitogen-activated protein kinase kinase 7.	0.935
MAP3K12	MAP3K13	ENSPPYP00000005225	ENSPPYP00000016066	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity).	0.902
MAP3K12	MAPK8IP1	ENSPPYP00000005225	ENSPPYP00000003821	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	MAPK8IP1 isoform 1.	0.474
MAP3K12	MBIP	ENSPPYP00000005225	ENSPPYP00000006532	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	MBIP isoform 1.	0.565
MAP3K12	MYCBP2	ENSPPYP00000005225	ENSPPYP00000024154	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	MYCBP2 isoform 1.	0.740
MAP3K12	TARS1	ENSPPYP00000005225	ENSPPYP00000017181	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	TARS isoform 1.	0.570
MAP3K12	TARS2	ENSPPYP00000005225	ENSPPYP00000001051	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	TARS2 isoform 3.	0.489
MAP3K12	TARS3	ENSPPYP00000005225	ENSPPYP00000007749	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	TARSL2 isoform 1.	0.489
MAP3K13	MAP2K7	ENSPPYP00000016066	ENSPPYP00000010648	Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity).	Mitogen-activated protein kinase kinase 7.	0.935
MAP3K13	MAP3K12	ENSPPYP00000016066	ENSPPYP00000005225	Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity).	Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.	0.902
MAP3K13	MAPK8IP1	ENSPPYP00000016066	ENSPPYP00000003821	Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity).	MAPK8IP1 isoform 1.	0.575
MAP3K13	MYCBP2	ENSPPYP00000016066	ENSPPYP00000024154	Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity).	MYCBP2 isoform 1.	0.740
MAPK8IP1	MAP2K7	ENSPPYP00000003821	ENSPPYP00000010648	MAPK8IP1 isoform 1.	Mitogen-activated protein kinase kinase 7.	0.985