| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBX3 | CBX5 | ENSPPYP00000019856 | ENSPPYP00000005247 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | CBX5 isoform 2. | 0.921 |
| CBX3 | CHAF1A | ENSPPYP00000019856 | ENSPPYP00000010547 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | CHAF1A isoform 1. | 0.831 |
| CBX3 | CHAF1B | ENSPPYP00000019856 | ENSPPYP00000012729 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Chromatin assembly factor 1 subunit B. | 0.599 |
| CBX3 | DSN1 | ENSPPYP00000019856 | ENSPPYP00000012257 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | DSN1 isoform 1. | 0.830 |
| CBX3 | H3-4 | ENSPPYP00000019856 | ENSPPYP00000000136 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Histone H3; Belongs to the histone H3 family. | 0.512 |
| CBX3 | NSL1 | ENSPPYP00000019856 | ENSPPYP00000000242 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | NSL1 component of MIS12 kinetochore complex. | 0.835 |
| CBX3 | PRR14 | ENSPPYP00000019856 | ENSPPYP00000008228 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | PRR14 isoform 6. | 0.543 |
| CBX3 | SUV39H1 | ENSPPYP00000019856 | ENSPPYP00000022743 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.945 |
| CBX3 | TRIM28 | ENSPPYP00000019856 | ENSPPYP00000011777 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | TRIM28 isoform 3. | 0.923 |
| CBX5 | CBX3 | ENSPPYP00000005247 | ENSPPYP00000019856 | CBX5 isoform 2. | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | 0.921 |
| CBX5 | CHAF1A | ENSPPYP00000005247 | ENSPPYP00000010547 | CBX5 isoform 2. | CHAF1A isoform 1. | 0.928 |
| CBX5 | CHAF1B | ENSPPYP00000005247 | ENSPPYP00000012729 | CBX5 isoform 2. | Chromatin assembly factor 1 subunit B. | 0.927 |
| CBX5 | DSN1 | ENSPPYP00000005247 | ENSPPYP00000012257 | CBX5 isoform 2. | DSN1 isoform 1. | 0.960 |
| CBX5 | H3-4 | ENSPPYP00000005247 | ENSPPYP00000000136 | CBX5 isoform 2. | Histone H3; Belongs to the histone H3 family. | 0.970 |
| CBX5 | NSL1 | ENSPPYP00000005247 | ENSPPYP00000000242 | CBX5 isoform 2. | NSL1 component of MIS12 kinetochore complex. | 0.907 |
| CBX5 | PRR14 | ENSPPYP00000005247 | ENSPPYP00000008228 | CBX5 isoform 2. | PRR14 isoform 6. | 0.937 |
| CBX5 | SP100 | ENSPPYP00000005247 | ENSPPYP00000014819 | CBX5 isoform 2. | SP100 isoform 3. | 0.927 |
| CBX5 | SUV39H1 | ENSPPYP00000005247 | ENSPPYP00000022743 | CBX5 isoform 2. | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.971 |
| CBX5 | TRIM28 | ENSPPYP00000005247 | ENSPPYP00000011777 | CBX5 isoform 2. | TRIM28 isoform 3. | 0.966 |
| CHAF1A | CBX3 | ENSPPYP00000010547 | ENSPPYP00000019856 | CHAF1A isoform 1. | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] | 0.831 |
