| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCNA1 | CCNA2 | ENSPPYP00000006017 | ENSPPYP00000016798 | CCNA1 isoform 3; Belongs to the cyclin family. | CCNA2 isoform 1; Belongs to the cyclin family. | 0.994 |
| CCNA1 | CCND1 | ENSPPYP00000006017 | ENSPPYP00000003434 | CCNA1 isoform 3; Belongs to the cyclin family. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.407 |
| CCNA1 | CCNE1 | ENSPPYP00000006017 | ENSPPYP00000010983 | CCNA1 isoform 3; Belongs to the cyclin family. | CCNE1 isoform 1; Belongs to the cyclin family. | 0.784 |
| CCNA1 | CCNE2 | ENSPPYP00000006017 | ENSPPYP00000021039 | CCNA1 isoform 3; Belongs to the cyclin family. | CCNE2 isoform 1; Belongs to the cyclin family. | 0.820 |
| CCNA1 | CDK2 | ENSPPYP00000006017 | ENSPPYP00000005283 | CCNA1 isoform 3; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
| CCNA1 | CDKN1A | ENSPPYP00000006017 | ENSPPYP00000018511 | CCNA1 isoform 3; Belongs to the cyclin family. | Cyclin dependent kinase inhibitor 1A. | 0.997 |
| CCNA1 | CDKN1B | ENSPPYP00000006017 | ENSPPYP00000004921 | CCNA1 isoform 3; Belongs to the cyclin family. | Cyclin dependent kinase inhibitor 1B. | 0.997 |
| CCNA1 | RB1 | ENSPPYP00000006017 | ENSPPYP00000006102 | CCNA1 isoform 3; Belongs to the cyclin family. | RB1 isoform 1. | 0.992 |
| CCNA1 | RBL2 | ENSPPYP00000006017 | ENSPPYP00000008300 | CCNA1 isoform 3; Belongs to the cyclin family. | RBL2 isoform 2. | 0.840 |
| CCNA1 | SKP2 | ENSPPYP00000006017 | ENSPPYP00000017203 | CCNA1 isoform 3; Belongs to the cyclin family. | SKP2 isoform 1. | 0.958 |
| CCNA2 | CCNA1 | ENSPPYP00000016798 | ENSPPYP00000006017 | CCNA2 isoform 1; Belongs to the cyclin family. | CCNA1 isoform 3; Belongs to the cyclin family. | 0.994 |
| CCNA2 | CCND1 | ENSPPYP00000016798 | ENSPPYP00000003434 | CCNA2 isoform 1; Belongs to the cyclin family. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.449 |
| CCNA2 | CCNE1 | ENSPPYP00000016798 | ENSPPYP00000010983 | CCNA2 isoform 1; Belongs to the cyclin family. | CCNE1 isoform 1; Belongs to the cyclin family. | 0.784 |
| CCNA2 | CCNE2 | ENSPPYP00000016798 | ENSPPYP00000021039 | CCNA2 isoform 1; Belongs to the cyclin family. | CCNE2 isoform 1; Belongs to the cyclin family. | 0.784 |
| CCNA2 | CDK2 | ENSPPYP00000016798 | ENSPPYP00000005283 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
| CCNA2 | CDKN1A | ENSPPYP00000016798 | ENSPPYP00000018511 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin dependent kinase inhibitor 1A. | 0.997 |
| CCNA2 | CDKN1B | ENSPPYP00000016798 | ENSPPYP00000004921 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin dependent kinase inhibitor 1B. | 0.997 |
| CCNA2 | RB1 | ENSPPYP00000016798 | ENSPPYP00000006102 | CCNA2 isoform 1; Belongs to the cyclin family. | RB1 isoform 1. | 0.998 |
| CCNA2 | RBL2 | ENSPPYP00000016798 | ENSPPYP00000008300 | CCNA2 isoform 1; Belongs to the cyclin family. | RBL2 isoform 2. | 0.969 |
| CCNA2 | SKP2 | ENSPPYP00000016798 | ENSPPYP00000017203 | CCNA2 isoform 1; Belongs to the cyclin family. | SKP2 isoform 1. | 0.983 |
