LRIG3 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COPS6	LRIG3	ENSPPYP00000019496	ENSPPYP00000005370	COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...]	Leucine rich repeats and immunoglobulin like domains 3.	0.546
ERBB2	LRIG1	ENSPPYP00000009527	ENSPPYP00000015363	Receptor protein-tyrosine kinase.	LRIG1 isoform 3.	0.850
ERBB2	LRIG3	ENSPPYP00000009527	ENSPPYP00000005370	Receptor protein-tyrosine kinase.	Leucine rich repeats and immunoglobulin like domains 3.	0.792
ERBB2	MET	ENSPPYP00000009527	ENSPPYP00000020106	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.884
ERBB2	MST1R	ENSPPYP00000009527	ENSPPYP00000015506	Receptor protein-tyrosine kinase.	MST1R isoform 1.	0.788
ERBB2	ROS1	ENSPPYP00000009527	ENSPPYP00000018987	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.458
FAM160A1	LRIG3	ENSPPYP00000016898	ENSPPYP00000005370	Family with sequence similarity 160 member A1.	Leucine rich repeats and immunoglobulin like domains 3.	0.556
GAL3ST1	LRIG1	ENSPPYP00000013068	ENSPPYP00000015363	GAL3ST1 isoform 1.	LRIG1 isoform 3.	0.743
GAL3ST1	LRIG3	ENSPPYP00000013068	ENSPPYP00000005370	GAL3ST1 isoform 1.	Leucine rich repeats and immunoglobulin like domains 3.	0.821
LRIG1	ERBB2	ENSPPYP00000015363	ENSPPYP00000009527	LRIG1 isoform 3.	Receptor protein-tyrosine kinase.	0.850
LRIG1	GAL3ST1	ENSPPYP00000015363	ENSPPYP00000013068	LRIG1 isoform 3.	GAL3ST1 isoform 1.	0.743
LRIG1	LRIG3	ENSPPYP00000015363	ENSPPYP00000005370	LRIG1 isoform 3.	Leucine rich repeats and immunoglobulin like domains 3.	0.807
LRIG1	MET	ENSPPYP00000015363	ENSPPYP00000020106	LRIG1 isoform 3.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.966
LRIG1	MST1R	ENSPPYP00000015363	ENSPPYP00000015506	LRIG1 isoform 3.	MST1R isoform 1.	0.796
LRIG3	COPS6	ENSPPYP00000005370	ENSPPYP00000019496	Leucine rich repeats and immunoglobulin like domains 3.	COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...]	0.546
LRIG3	ERBB2	ENSPPYP00000005370	ENSPPYP00000009527	Leucine rich repeats and immunoglobulin like domains 3.	Receptor protein-tyrosine kinase.	0.792
LRIG3	FAM160A1	ENSPPYP00000005370	ENSPPYP00000016898	Leucine rich repeats and immunoglobulin like domains 3.	Family with sequence similarity 160 member A1.	0.556
LRIG3	GAL3ST1	ENSPPYP00000005370	ENSPPYP00000013068	Leucine rich repeats and immunoglobulin like domains 3.	GAL3ST1 isoform 1.	0.821
LRIG3	LRIG1	ENSPPYP00000005370	ENSPPYP00000015363	Leucine rich repeats and immunoglobulin like domains 3.	LRIG1 isoform 3.	0.807
LRIG3	MET	ENSPPYP00000005370	ENSPPYP00000020106	Leucine rich repeats and immunoglobulin like domains 3.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.656