Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1085 aa)    
Predicted Functional Partners:
ROBO1
ROBO1 isoform 6.
    
 0.972
CDC42
Cell division cycle 42.
   
 0.965
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2.
  
0.964
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3.
  
 
0.946
ROBO2
ROBO2 isoform 6.
    
 0.934
USP30
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
      
 0.778
FLRT2
Fibronectin leucine rich transmembrane protein 2.
     
 0.710
SSH1
SSH1 isoform 1.
      
 0.695
PTP4A1
Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
      
 0.687
ITSN2
ITSN2 isoform 3.
   
 0.685
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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