TBK1 protein (Pongo abelii) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

TBK1

TANK binding kinase 1. (729 aa)

Predicted Functional Partners:

IKBKE

0.999

TRAF3

0.999

IRF3

0.999

MAVS

0.999

TANK

0.999

AZI2

0.999

STING1

0.999

TRAF6

0.997

TNF

0.995

IKBKG

0.994

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AZI2	IKBKE	ENSPPYP00000015723	ENSPPYP00000000308	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.916
AZI2	IKBKG	ENSPPYP00000015723	ENSPPYP00000023381	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.948
AZI2	IRF3	ENSPPYP00000015723	ENSPPYP00000011485	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	IRF3 isoform 6.	0.457
AZI2	TANK	ENSPPYP00000015723	ENSPPYP00000014373	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	TANK isoform 2.	0.934
AZI2	TBK1	ENSPPYP00000015723	ENSPPYP00000005386	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	TANK binding kinase 1.	0.999
AZI2	TNF	ENSPPYP00000015723	ENSPPYP00000018379	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family.	0.987
AZI2	TRAF3	ENSPPYP00000015723	ENSPPYP00000007003	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.589
IKBKE	AZI2	ENSPPYP00000000308	ENSPPYP00000015723	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	0.916
IKBKE	IKBKG	ENSPPYP00000000308	ENSPPYP00000023381	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.985
IKBKE	IRF3	ENSPPYP00000000308	ENSPPYP00000011485	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	IRF3 isoform 6.	0.987
IKBKE	MAVS	ENSPPYP00000000308	ENSPPYP00000012072	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	MAVS isoform 2.	0.999
IKBKE	STING1	ENSPPYP00000000308	ENSPPYP00000017715	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Transmembrane protein 173.	0.990
IKBKE	TANK	ENSPPYP00000000308	ENSPPYP00000014373	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TANK isoform 2.	0.998
IKBKE	TBK1	ENSPPYP00000000308	ENSPPYP00000005386	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TANK binding kinase 1.	0.999
IKBKE	TNF	ENSPPYP00000000308	ENSPPYP00000018379	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family.	0.994
IKBKE	TRAF3	ENSPPYP00000000308	ENSPPYP00000007003	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
IKBKE	TRAF6	ENSPPYP00000000308	ENSPPYP00000003845	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.997
IKBKG	AZI2	ENSPPYP00000023381	ENSPPYP00000015723	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF- alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity).	0.948
IKBKG	IKBKE	ENSPPYP00000023381	ENSPPYP00000000308	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.985
IKBKG	IRF3	ENSPPYP00000023381	ENSPPYP00000011485	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	IRF3 isoform 6.	0.460