| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IL1R1 | IRAK1 | ENSPPYP00000013505 | ENSPPYP00000023353 | Interleukin 1 receptor type 1. | Interleukin 1 receptor associated kinase 1. | 0.980 |
| IL1R1 | IRAK2 | ENSPPYP00000013505 | ENSPPYP00000015274 | Interleukin 1 receptor type 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.877 |
| IL1R1 | IRAK3 | ENSPPYP00000013505 | ENSPPYP00000005399 | Interleukin 1 receptor type 1. | IRAK3 isoform 1. | 0.677 |
| IL1R1 | IRAK4 | ENSPPYP00000013505 | ENSPPYP00000005053 | Interleukin 1 receptor type 1. | IRAK4 isoform 6. | 0.891 |
| IL1R1 | MYD88 | ENSPPYP00000013505 | ENSPPYP00000015673 | Interleukin 1 receptor type 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.984 |
| IL1R1 | TLR2 | ENSPPYP00000013505 | ENSPPYP00000016910 | Interleukin 1 receptor type 1. | Toll-like receptor. | 0.597 |
| IL1R1 | TOLLIP | ENSPPYP00000013505 | ENSPPYP00000003370 | Interleukin 1 receptor type 1. | Toll interacting protein. | 0.876 |
| IL1R1 | TRAF6 | ENSPPYP00000013505 | ENSPPYP00000003845 | Interleukin 1 receptor type 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.951 |
| IRAK1 | IL1R1 | ENSPPYP00000023353 | ENSPPYP00000013505 | Interleukin 1 receptor associated kinase 1. | Interleukin 1 receptor type 1. | 0.980 |
| IRAK1 | IRAK2 | ENSPPYP00000023353 | ENSPPYP00000015274 | Interleukin 1 receptor associated kinase 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.991 |
| IRAK1 | IRAK3 | ENSPPYP00000023353 | ENSPPYP00000005399 | Interleukin 1 receptor associated kinase 1. | IRAK3 isoform 1. | 0.919 |
| IRAK1 | IRAK4 | ENSPPYP00000023353 | ENSPPYP00000005053 | Interleukin 1 receptor associated kinase 1. | IRAK4 isoform 6. | 0.999 |
| IRAK1 | MYD88 | ENSPPYP00000023353 | ENSPPYP00000015673 | Interleukin 1 receptor associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.999 |
| IRAK1 | NGFR | ENSPPYP00000023353 | ENSPPYP00000010010 | Interleukin 1 receptor associated kinase 1. | NGFR isoform 1. | 0.955 |
| IRAK1 | SIGIRR | ENSPPYP00000023353 | ENSPPYP00000003329 | Interleukin 1 receptor associated kinase 1. | SIGIRR isoform 11. | 0.541 |
| IRAK1 | TLR2 | ENSPPYP00000023353 | ENSPPYP00000016910 | Interleukin 1 receptor associated kinase 1. | Toll-like receptor. | 0.694 |
| IRAK1 | TOLLIP | ENSPPYP00000023353 | ENSPPYP00000003370 | Interleukin 1 receptor associated kinase 1. | Toll interacting protein. | 0.974 |
| IRAK1 | TRAF6 | ENSPPYP00000023353 | ENSPPYP00000003845 | Interleukin 1 receptor associated kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |
| IRAK2 | IL1R1 | ENSPPYP00000015274 | ENSPPYP00000013505 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | Interleukin 1 receptor type 1. | 0.877 |
| IRAK2 | IRAK1 | ENSPPYP00000015274 | ENSPPYP00000023353 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | Interleukin 1 receptor associated kinase 1. | 0.991 |
