| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IFNAR1 | IFNG | ENSPPYP00000012695 | ENSPPYP00000005405 | IFNAR1 isoform 2. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.950 |
| IFNAR1 | IFNGR1 | ENSPPYP00000012695 | ENSPPYP00000019082 | IFNAR1 isoform 2. | IFNGR1 isoform 1. | 0.972 |
| IFNAR1 | IFNGR2 | ENSPPYP00000012695 | ENSPPYP00000024122 | IFNAR1 isoform 2. | IFNGR2 isoform 1. | 0.926 |
| IFNAR1 | IL10 | ENSPPYP00000012695 | ENSPPYP00000000299 | IFNAR1 isoform 2. | IL10 isoform 1. | 0.831 |
| IFNAR1 | JAK1 | ENSPPYP00000012695 | ENSPPYP00000001481 | IFNAR1 isoform 2. | Tyrosine-protein kinase. | 0.997 |
| IFNAR1 | JAK2 | ENSPPYP00000012695 | ENSPPYP00000021551 | IFNAR1 isoform 2. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.967 |
| IFNAR1 | TNF | ENSPPYP00000012695 | ENSPPYP00000018379 | IFNAR1 isoform 2. | Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. | 0.423 |
| IFNG | IFNAR1 | ENSPPYP00000005405 | ENSPPYP00000012695 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | IFNAR1 isoform 2. | 0.950 |
| IFNG | IFNGR1 | ENSPPYP00000005405 | ENSPPYP00000019082 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | IFNGR1 isoform 1. | 0.998 |
| IFNG | IFNGR2 | ENSPPYP00000005405 | ENSPPYP00000024122 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | IFNGR2 isoform 1. | 0.995 |
| IFNG | IL10 | ENSPPYP00000005405 | ENSPPYP00000000299 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | IL10 isoform 1. | 0.945 |
| IFNG | JAK1 | ENSPPYP00000005405 | ENSPPYP00000001481 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Tyrosine-protein kinase. | 0.976 |
| IFNG | JAK2 | ENSPPYP00000005405 | ENSPPYP00000021551 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.975 |
| IFNG | LEP | ENSPPYP00000005405 | ENSPPYP00000020162 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.942 |
| IFNG | PSME1 | ENSPPYP00000005405 | ENSPPYP00000006462 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Proteasome activator subunit 1. | 0.940 |
| IFNG | PSME2 | ENSPPYP00000005405 | ENSPPYP00000006464 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Proteasome activator subunit 2. | 0.948 |
| IFNG | TNF | ENSPPYP00000005405 | ENSPPYP00000018379 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. | 0.972 |
| IFNGR1 | IFNAR1 | ENSPPYP00000019082 | ENSPPYP00000012695 | IFNGR1 isoform 1. | IFNAR1 isoform 2. | 0.972 |
| IFNGR1 | IFNG | ENSPPYP00000019082 | ENSPPYP00000005405 | IFNGR1 isoform 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.998 |
| IFNGR1 | IFNGR2 | ENSPPYP00000019082 | ENSPPYP00000024122 | IFNGR1 isoform 1. | IFNGR2 isoform 1. | 0.996 |
