| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT1 | AKT2 | ENSPPYP00000007036 | ENSPPYP00000011178 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.999 |
| AKT1 | AKT3 | ENSPPYP00000007036 | ENSPPYP00000000057 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.991 |
| AKT1 | ATM | ENSPPYP00000007036 | ENSPPYP00000004403 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.566 |
| AKT1 | IRF1 | ENSPPYP00000007036 | ENSPPYP00000017628 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Interferon regulatory factor. | 0.453 |
| AKT1 | MDM2 | ENSPPYP00000007036 | ENSPPYP00000005415 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.984 |
| AKT1 | MDM4 | ENSPPYP00000007036 | ENSPPYP00000000346 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.583 |
| AKT1 | TP53 | ENSPPYP00000007036 | ENSPPYP00000008923 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.979 |
| AKT2 | AKT1 | ENSPPYP00000011178 | ENSPPYP00000007036 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.999 |
| AKT2 | AKT3 | ENSPPYP00000011178 | ENSPPYP00000000057 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.984 |
| AKT2 | ATM | ENSPPYP00000011178 | ENSPPYP00000004403 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.425 |
| AKT2 | MDM2 | ENSPPYP00000011178 | ENSPPYP00000005415 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.976 |
| AKT2 | MDM4 | ENSPPYP00000011178 | ENSPPYP00000000346 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.545 |
| AKT2 | TP53 | ENSPPYP00000011178 | ENSPPYP00000008923 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.945 |
| AKT3 | AKT1 | ENSPPYP00000000057 | ENSPPYP00000007036 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.991 |
| AKT3 | AKT2 | ENSPPYP00000000057 | ENSPPYP00000011178 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.984 |
| AKT3 | ATM | ENSPPYP00000000057 | ENSPPYP00000004403 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.425 |
| AKT3 | MDM2 | ENSPPYP00000000057 | ENSPPYP00000005415 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.976 |
| AKT3 | MDM4 | ENSPPYP00000000057 | ENSPPYP00000000346 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.547 |
| AKT3 | TP53 | ENSPPYP00000000057 | ENSPPYP00000008923 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.945 |
| ATM | AKT1 | ENSPPYP00000004403 | ENSPPYP00000007036 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.566 |
