LGR5 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

LGR5

LGR5 isoform 1. (907 aa)

Predicted Functional Partners:

RSPO1

0.996

LGR4

0.995

RSPO3

0.991

LRP6

0.946

ZNRF3

0.937

RNF43

0.934

LGR6

0.927

FZD6

0.925

CR201_G0005637

0.884

RSPO4

0.849

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0005637	LGR4	ENSPPYP00000021114	ENSPPYP00000003909	RSPO2 isoform 1.	LGR4 isoform 1.	0.984
CR201_G0005637	LGR5	ENSPPYP00000021114	ENSPPYP00000005437	RSPO2 isoform 1.	LGR5 isoform 1.	0.884
CR201_G0005637	LGR6	ENSPPYP00000021114	ENSPPYP00000000389	RSPO2 isoform 1.	LGR6 isoform 2.	0.634
CR201_G0005637	RNF43	ENSPPYP00000021114	ENSPPYP00000009250	RSPO2 isoform 1.	RNF43 isoform 2.	0.924
CR201_G0005637	RSPO1	ENSPPYP00000021114	ENSPPYP00000001764	RSPO2 isoform 1.	RSPO1 isoform 1.	0.449
CR201_G0005637	RSPO3	ENSPPYP00000021114	ENSPPYP00000019027	RSPO2 isoform 1.	RSPO3 isoform 2.	0.422
CR201_G0005637	RSPO4	ENSPPYP00000021114	ENSPPYP00000012130	RSPO2 isoform 1.	RSPO4 isoform 2.	0.511
CR201_G0005637	ZNRF3	ENSPPYP00000021114	ENSPPYP00000013028	RSPO2 isoform 1.	ZNRF3 isoform 2.	0.971
FZD6	LGR4	ENSPPYP00000021096	ENSPPYP00000003909	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	LGR4 isoform 1.	0.705
FZD6	LGR5	ENSPPYP00000021096	ENSPPYP00000005437	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	LGR5 isoform 1.	0.925
FZD6	LRP6	ENSPPYP00000021096	ENSPPYP00000024153	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.972
FZD6	RNF43	ENSPPYP00000021096	ENSPPYP00000009250	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	RNF43 isoform 2.	0.954
FZD6	ZNRF3	ENSPPYP00000021096	ENSPPYP00000013028	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	ZNRF3 isoform 2.	0.959
LGR4	CR201_G0005637	ENSPPYP00000003909	ENSPPYP00000021114	LGR4 isoform 1.	RSPO2 isoform 1.	0.984
LGR4	FZD6	ENSPPYP00000003909	ENSPPYP00000021096	LGR4 isoform 1.	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	0.705
LGR4	LGR5	ENSPPYP00000003909	ENSPPYP00000005437	LGR4 isoform 1.	LGR5 isoform 1.	0.995
LGR4	LGR6	ENSPPYP00000003909	ENSPPYP00000000389	LGR4 isoform 1.	LGR6 isoform 2.	0.924
LGR4	LRP6	ENSPPYP00000003909	ENSPPYP00000024153	LGR4 isoform 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.946
LGR4	RNF43	ENSPPYP00000003909	ENSPPYP00000009250	LGR4 isoform 1.	RNF43 isoform 2.	0.897
LGR4	RSPO1	ENSPPYP00000003909	ENSPPYP00000001764	LGR4 isoform 1.	RSPO1 isoform 1.	0.998