TDG protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB10	TDG	ENSPPYP00000000127	ENSPPYP00000005581	ABCB10 isoform 1.	Thymine DNA glycosylase.	0.804
APEX1	CREBBP	ENSPPYP00000006334	ENSPPYP00000007974	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	CREBBP isoform 1.	0.582
APEX1	MBD4	ENSPPYP00000006334	ENSPPYP00000015005	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	0.640
APEX1	SMUG1	ENSPPYP00000006334	ENSPPYP00000005246	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	SMUG1 isoform 14.	0.761
APEX1	TDG	ENSPPYP00000006334	ENSPPYP00000005581	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Thymine DNA glycosylase.	0.770
CR201_G0007169	CREBBP	ENSPPYP00000000742	ENSPPYP00000007974	SUMO1 isoform 5.	CREBBP isoform 1.	0.831
CR201_G0007169	SUMO1	ENSPPYP00000000742	ENSPPYP00000014619	SUMO1 isoform 5.	Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...]	0.801
CR201_G0007169	SUMO2	ENSPPYP00000000742	ENSPPYP00000023768	SUMO1 isoform 5.	Small ubiquitin-related modifier.	0.586
CR201_G0007169	SUMO3	ENSPPYP00000000742	ENSPPYP00000012841	SUMO1 isoform 5.	Small ubiquitin-related modifier.	0.586
CR201_G0007169	TDG	ENSPPYP00000000742	ENSPPYP00000005581	SUMO1 isoform 5.	Thymine DNA glycosylase.	0.863
CR201_G0007169	UBE2I	ENSPPYP00000000742	ENSPPYP00000007864	SUMO1 isoform 5.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.978
CREBBP	APEX1	ENSPPYP00000007974	ENSPPYP00000006334	CREBBP isoform 1.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.582
CREBBP	CR201_G0007169	ENSPPYP00000007974	ENSPPYP00000000742	CREBBP isoform 1.	SUMO1 isoform 5.	0.831
CREBBP	SUMO1	ENSPPYP00000007974	ENSPPYP00000014619	CREBBP isoform 1.	Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...]	0.831
CREBBP	SUMO2	ENSPPYP00000007974	ENSPPYP00000023768	CREBBP isoform 1.	Small ubiquitin-related modifier.	0.402
CREBBP	SUMO3	ENSPPYP00000007974	ENSPPYP00000012841	CREBBP isoform 1.	Small ubiquitin-related modifier.	0.402
CREBBP	TDG	ENSPPYP00000007974	ENSPPYP00000005581	CREBBP isoform 1.	Thymine DNA glycosylase.	0.842
CREBBP	UBE2I	ENSPPYP00000007974	ENSPPYP00000007864	CREBBP isoform 1.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.860
MBD4	APEX1	ENSPPYP00000015005	ENSPPYP00000006334	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.640
MBD4	SMUG1	ENSPPYP00000015005	ENSPPYP00000005246	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	SMUG1 isoform 14.	0.767