| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC13 | CCDC14 | ENSPPYP00000015632 | ENSPPYP00000015065 | Coiled-coil domain-containing protein 13. | CCDC14 isoform 1. | 0.504 |
| CCDC13 | TCHP | ENSPPYP00000015632 | ENSPPYP00000005637 | Coiled-coil domain-containing protein 13. | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | 0.499 |
| CCDC14 | CCDC13 | ENSPPYP00000015065 | ENSPPYP00000015632 | CCDC14 isoform 1. | Coiled-coil domain-containing protein 13. | 0.504 |
| CCDC14 | TCHP | ENSPPYP00000015065 | ENSPPYP00000005637 | CCDC14 isoform 1. | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | 0.524 |
| CDR2 | TCHP | ENSPPYP00000008121 | ENSPPYP00000005637 | Cerebellar degeneration related protein 2. | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | 0.750 |
| ENSPPYP00000000624 | TCHP | ENSPPYP00000000624 | ENSPPYP00000005637 | annotation not available | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | 0.682 |
| GLUL | TCHP | ENSPPYP00000000500 | ENSPPYP00000005637 | Glutamine synthetase. | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | 0.502 |
| IFFO1 | TCHP | ENSPPYP00000004775 | ENSPPYP00000005637 | Intermediate filament family orphan 1; Belongs to the intermediate filament family. | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | 0.492 |
| MDM2 | PTEN | ENSPPYP00000005415 | ENSPPYP00000002838 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.654 |
| MDM2 | TCHP | ENSPPYP00000005415 | ENSPPYP00000005637 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | 0.584 |
| MDM2 | TP53 | ENSPPYP00000005415 | ENSPPYP00000008923 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.999 |
| MFN2 | TCHP | ENSPPYP00000002168 | ENSPPYP00000005637 | MFN2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | 0.712 |
| PTEN | MDM2 | ENSPPYP00000002838 | ENSPPYP00000005415 | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.654 |
| PTEN | TCHP | ENSPPYP00000002838 | ENSPPYP00000005637 | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | 0.521 |
| PTEN | TP53 | ENSPPYP00000002838 | ENSPPYP00000008923 | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.995 |
| TCHP | CCDC13 | ENSPPYP00000005637 | ENSPPYP00000015632 | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | Coiled-coil domain-containing protein 13. | 0.499 |
| TCHP | CCDC14 | ENSPPYP00000005637 | ENSPPYP00000015065 | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | CCDC14 isoform 1. | 0.524 |
| TCHP | CDR2 | ENSPPYP00000005637 | ENSPPYP00000008121 | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | Cerebellar degeneration related protein 2. | 0.750 |
| TCHP | ENSPPYP00000000624 | ENSPPYP00000005637 | ENSPPYP00000000624 | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | annotation not available | 0.682 |
| TCHP | GLUL | ENSPPYP00000005637 | ENSPPYP00000000500 | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. | Glutamine synthetase. | 0.502 |
