ENSPPYP00000005659 protein (Pongo abelii) - STRING interaction network

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNAJA1	DNAJB1	ENSPPYP00000021446	ENSPPYP00000010811	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DnaJ heat shock protein family (Hsp40) member B1.	0.779
DNAJA1	ENSPPYP00000005659	ENSPPYP00000021446	ENSPPYP00000005659	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	annotation not available	0.970
DNAJA1	ENSPPYP00000017062	ENSPPYP00000021446	ENSPPYP00000017062	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	annotation not available	0.801
DNAJA1	ENSPPYP00000024257	ENSPPYP00000021446	ENSPPYP00000024257	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	LOW QUALITY PROTEIN: stress-70 protein, mitochondrial-like.	0.725
DNAJA1	HSP90AA1	ENSPPYP00000021446	ENSPPYP00000006994	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	HSP90AA1 isoform 6.	0.801
DNAJA1	HSP90AB1	ENSPPYP00000021446	ENSPPYP00000018631	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.832
DNAJA1	HSPA1L	ENSPPYP00000021446	ENSPPYP00000018406	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.909
DNAJA1	HSPA2	ENSPPYP00000021446	ENSPPYP00000006709	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.928
DNAJA1	HSPA4	ENSPPYP00000021446	ENSPPYP00000017643	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.842
DNAJA1	HSPA5	ENSPPYP00000021446	ENSPPYP00000021973	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.884
DNAJB1	DNAJA1	ENSPPYP00000010811	ENSPPYP00000021446	DnaJ heat shock protein family (Hsp40) member B1.	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	0.779
DNAJB1	ENSPPYP00000005659	ENSPPYP00000010811	ENSPPYP00000005659	DnaJ heat shock protein family (Hsp40) member B1.	annotation not available	0.952
DNAJB1	ENSPPYP00000017062	ENSPPYP00000010811	ENSPPYP00000017062	DnaJ heat shock protein family (Hsp40) member B1.	annotation not available	0.768
DNAJB1	ENSPPYP00000024257	ENSPPYP00000010811	ENSPPYP00000024257	DnaJ heat shock protein family (Hsp40) member B1.	LOW QUALITY PROTEIN: stress-70 protein, mitochondrial-like.	0.800
DNAJB1	HSP90AA1	ENSPPYP00000010811	ENSPPYP00000006994	DnaJ heat shock protein family (Hsp40) member B1.	HSP90AA1 isoform 6.	0.768
DNAJB1	HSP90AB1	ENSPPYP00000010811	ENSPPYP00000018631	DnaJ heat shock protein family (Hsp40) member B1.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.850
DNAJB1	HSPA1L	ENSPPYP00000010811	ENSPPYP00000018406	DnaJ heat shock protein family (Hsp40) member B1.	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.952
DNAJB1	HSPA2	ENSPPYP00000010811	ENSPPYP00000006709	DnaJ heat shock protein family (Hsp40) member B1.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.950
DNAJB1	HSPA4	ENSPPYP00000010811	ENSPPYP00000017643	DnaJ heat shock protein family (Hsp40) member B1.	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.989
DNAJB1	HSPA5	ENSPPYP00000010811	ENSPPYP00000021973	DnaJ heat shock protein family (Hsp40) member B1.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.864