ENSPPYP00000005659 protein (Pongo abelii) - STRING interaction network

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

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[Homology]

Score

ENSPPYP00000005659

annotation not available (212 aa)

Predicted Functional Partners:

DNAJC6

0.994

STIP1

0.975

BAG2

0.971

HSPA4

0.969

BAG1

0.966

DNAJB1

0.965

HSPH1

0.962

STUB1

0.960

DNAJA1

0.958

GAK

0.957

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG1	BAG2	ENSPPYP00000021443	ENSPPYP00000018729	BAG1 isoform 2.	BCL2 associated athanogene 2.	0.987
BAG1	DNAJA1	ENSPPYP00000021443	ENSPPYP00000021446	BAG1 isoform 2.	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	0.480
BAG1	DNAJB1	ENSPPYP00000021443	ENSPPYP00000010811	BAG1 isoform 2.	DnaJ heat shock protein family (Hsp40) member B1.	0.835
BAG1	ENSPPYP00000005659	ENSPPYP00000021443	ENSPPYP00000005659	BAG1 isoform 2.	annotation not available	0.966
BAG1	HSPA4	ENSPPYP00000021443	ENSPPYP00000017643	BAG1 isoform 2.	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.987
BAG1	HSPH1	ENSPPYP00000021443	ENSPPYP00000005987	BAG1 isoform 2.	Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.	0.958
BAG1	STIP1	ENSPPYP00000021443	ENSPPYP00000003602	BAG1 isoform 2.	STIP1 isoform 2.	0.534
BAG1	STUB1	ENSPPYP00000021443	ENSPPYP00000007837	BAG1 isoform 2.	STIP1 homology and U-box containing protein 1.	0.940
BAG2	BAG1	ENSPPYP00000018729	ENSPPYP00000021443	BCL2 associated athanogene 2.	BAG1 isoform 2.	0.987
BAG2	DNAJB1	ENSPPYP00000018729	ENSPPYP00000010811	BCL2 associated athanogene 2.	DnaJ heat shock protein family (Hsp40) member B1.	0.671
BAG2	DNAJC6	ENSPPYP00000018729	ENSPPYP00000011932	BCL2 associated athanogene 2.	DNAJC6 isoform 6.	0.437
BAG2	ENSPPYP00000005659	ENSPPYP00000018729	ENSPPYP00000005659	BCL2 associated athanogene 2.	annotation not available	0.971
BAG2	GAK	ENSPPYP00000018729	ENSPPYP00000016219	BCL2 associated athanogene 2.	GAK isoform 7.	0.447
BAG2	HSPA4	ENSPPYP00000018729	ENSPPYP00000017643	BCL2 associated athanogene 2.	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.932
BAG2	HSPH1	ENSPPYP00000018729	ENSPPYP00000005987	BCL2 associated athanogene 2.	Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.	0.985
BAG2	STUB1	ENSPPYP00000018729	ENSPPYP00000007837	BCL2 associated athanogene 2.	STIP1 homology and U-box containing protein 1.	0.950
DNAJA1	BAG1	ENSPPYP00000021446	ENSPPYP00000021443	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	BAG1 isoform 2.	0.480
DNAJA1	DNAJB1	ENSPPYP00000021446	ENSPPYP00000010811	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DnaJ heat shock protein family (Hsp40) member B1.	0.782
DNAJA1	DNAJC6	ENSPPYP00000021446	ENSPPYP00000011932	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	DNAJC6 isoform 6.	0.406
DNAJA1	ENSPPYP00000005659	ENSPPYP00000021446	ENSPPYP00000005659	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity).	annotation not available	0.958