| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGFR | GAB1 | ENSPPYP00000019671 | ENSPPYP00000016856 | Receptor protein-tyrosine kinase. | GAB1 isoform 1. | 0.996 |
| EGFR | GRB2 | ENSPPYP00000019671 | ENSPPYP00000009686 | Receptor protein-tyrosine kinase. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | 0.999 |
| EGFR | JAK2 | ENSPPYP00000019671 | ENSPPYP00000021551 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.983 |
| EGFR | PDGFRB | ENSPPYP00000019671 | ENSPPYP00000017839 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.978 |
| EGFR | PECAM1 | ENSPPYP00000019671 | ENSPPYP00000009599 | Receptor protein-tyrosine kinase. | PECAM1 isoform 1. | 0.429 |
| EGFR | PIK3CA | ENSPPYP00000019671 | ENSPPYP00000023529 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.997 |
| EGFR | PIK3R1 | ENSPPYP00000019671 | ENSPPYP00000017341 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.997 |
| EGFR | PTPN11 | ENSPPYP00000019671 | ENSPPYP00000005677 | Receptor protein-tyrosine kinase. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.997 |
| EGFR | SOS1 | ENSPPYP00000019671 | ENSPPYP00000013933 | Receptor protein-tyrosine kinase. | SOS1 isoform 2. | 0.996 |
| GAB1 | EGFR | ENSPPYP00000016856 | ENSPPYP00000019671 | GAB1 isoform 1. | Receptor protein-tyrosine kinase. | 0.996 |
| GAB1 | GRB2 | ENSPPYP00000016856 | ENSPPYP00000009686 | GAB1 isoform 1. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | 0.999 |
| GAB1 | JAK2 | ENSPPYP00000016856 | ENSPPYP00000021551 | GAB1 isoform 1. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.551 |
| GAB1 | PDGFRB | ENSPPYP00000016856 | ENSPPYP00000017839 | GAB1 isoform 1. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.930 |
| GAB1 | PIK3CA | ENSPPYP00000016856 | ENSPPYP00000023529 | GAB1 isoform 1. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.978 |
| GAB1 | PIK3R1 | ENSPPYP00000016856 | ENSPPYP00000017341 | GAB1 isoform 1. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.996 |
| GAB1 | PTPN11 | ENSPPYP00000016856 | ENSPPYP00000005677 | GAB1 isoform 1. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.998 |
| GAB1 | SOS1 | ENSPPYP00000016856 | ENSPPYP00000013933 | GAB1 isoform 1. | SOS1 isoform 2. | 0.974 |
| GRB2 | EGFR | ENSPPYP00000009686 | ENSPPYP00000019671 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Receptor protein-tyrosine kinase. | 0.999 |
| GRB2 | GAB1 | ENSPPYP00000009686 | ENSPPYP00000016856 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | GAB1 isoform 1. | 0.999 |
| GRB2 | JAK2 | ENSPPYP00000009686 | ENSPPYP00000021551 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.888 |
