node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | BIRC2 | ENSPPYP00000005543 | ENSPPYP00000004356 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 2. | 0.790 |
APAF1 | BIRC5 | ENSPPYP00000005543 | ENSPPYP00000009754 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | 0.693 |
APAF1 | BIRC6 | ENSPPYP00000005543 | ENSPPYP00000013966 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BIRC6 isoform 1. | 0.937 |
APAF1 | BIRC7 | ENSPPYP00000005543 | ENSPPYP00000012543 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 7. | 0.723 |
APAF1 | CASP3 | ENSPPYP00000005543 | ENSPPYP00000017020 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.995 |
APAF1 | CASP7 | ENSPPYP00000005543 | ENSPPYP00000003106 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP7 isoform 4; Belongs to the peptidase C14A family. | 0.873 |
APAF1 | CASP9 | ENSPPYP00000005543 | ENSPPYP00000002138 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP9 isoform 2; Belongs to the peptidase C14A family. | 0.999 |
APAF1 | CYCS | ENSPPYP00000005543 | ENSPPYP00000019862 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.999 |
APAF1 | DIABLO | ENSPPYP00000005543 | ENSPPYP00000005770 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Diablo homolog, mitochondrial; Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity). | 0.948 |
APAF1 | XIAP | ENSPPYP00000005543 | ENSPPYP00000023167 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | XIAP isoform 2. | 0.913 |
BIRC2 | APAF1 | ENSPPYP00000004356 | ENSPPYP00000005543 | Baculoviral IAP repeat containing 2. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.790 |
BIRC2 | BIRC5 | ENSPPYP00000004356 | ENSPPYP00000009754 | Baculoviral IAP repeat containing 2. | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | 0.933 |
BIRC2 | BIRC7 | ENSPPYP00000004356 | ENSPPYP00000012543 | Baculoviral IAP repeat containing 2. | Baculoviral IAP repeat containing 7. | 0.986 |
BIRC2 | CASP3 | ENSPPYP00000004356 | ENSPPYP00000017020 | Baculoviral IAP repeat containing 2. | CASP3 isoform 1; Belongs to the peptidase C14A family. | 0.995 |
BIRC2 | CASP7 | ENSPPYP00000004356 | ENSPPYP00000003106 | Baculoviral IAP repeat containing 2. | CASP7 isoform 4; Belongs to the peptidase C14A family. | 0.996 |
BIRC2 | CASP9 | ENSPPYP00000004356 | ENSPPYP00000002138 | Baculoviral IAP repeat containing 2. | CASP9 isoform 2; Belongs to the peptidase C14A family. | 0.997 |
BIRC2 | CYCS | ENSPPYP00000004356 | ENSPPYP00000019862 | Baculoviral IAP repeat containing 2. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.562 |
BIRC2 | DIABLO | ENSPPYP00000004356 | ENSPPYP00000005770 | Baculoviral IAP repeat containing 2. | Diablo homolog, mitochondrial; Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity). | 0.997 |
BIRC2 | XIAP | ENSPPYP00000004356 | ENSPPYP00000023167 | Baculoviral IAP repeat containing 2. | XIAP isoform 2. | 0.997 |
BIRC5 | APAF1 | ENSPPYP00000009754 | ENSPPYP00000005543 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.693 |