LATS2 protein (Pongo abelii) - STRING interaction network

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Predicted Interactions

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Score

LATS2

Non-specific serine/threonine protein kinase. (1098 aa)

Predicted Functional Partners:

YAP1

0.997

LATS1

0.991

WWTR1

0.986

MOB1B

0.981

MOB1A

0.980

SAV1

0.976

STK3

0.972

AJUBA

0.967

NF2

0.961

WTIP

0.946

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJUBA	LATS1	ENSPPYP00000006424	ENSPPYP00000019136	LIM domain-containing protein ajuba isoform X1.	Large tumor suppressor kinase 1.	0.955
AJUBA	LATS2	ENSPPYP00000006424	ENSPPYP00000005920	LIM domain-containing protein ajuba isoform X1.	Non-specific serine/threonine protein kinase.	0.967
AJUBA	SAV1	ENSPPYP00000006424	ENSPPYP00000006597	LIM domain-containing protein ajuba isoform X1.	Salvador family WW domain containing protein 1.	0.930
AJUBA	WTIP	ENSPPYP00000006424	ENSPPYP00000011015	LIM domain-containing protein ajuba isoform X1.	WTIP isoform 1.	0.941
LATS1	AJUBA	ENSPPYP00000019136	ENSPPYP00000006424	Large tumor suppressor kinase 1.	LIM domain-containing protein ajuba isoform X1.	0.955
LATS1	LATS2	ENSPPYP00000019136	ENSPPYP00000005920	Large tumor suppressor kinase 1.	Non-specific serine/threonine protein kinase.	0.991
LATS1	MOB1A	ENSPPYP00000019136	ENSPPYP00000013698	Large tumor suppressor kinase 1.	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	0.991
LATS1	MOB1B	ENSPPYP00000019136	ENSPPYP00000016542	Large tumor suppressor kinase 1.	MOB kinase activator 1B.	0.992
LATS1	NF2	ENSPPYP00000019136	ENSPPYP00000013046	Large tumor suppressor kinase 1.	Neurofibromin 2.	0.966
LATS1	SAV1	ENSPPYP00000019136	ENSPPYP00000006597	Large tumor suppressor kinase 1.	Salvador family WW domain containing protein 1.	0.975
LATS1	STK3	ENSPPYP00000019136	ENSPPYP00000021064	Large tumor suppressor kinase 1.	STK3 isoform 3.	0.992
LATS1	WTIP	ENSPPYP00000019136	ENSPPYP00000011015	Large tumor suppressor kinase 1.	WTIP isoform 1.	0.955
LATS1	WWTR1	ENSPPYP00000019136	ENSPPYP00000015879	Large tumor suppressor kinase 1.	WW domain containing transcription regulator 1.	0.996
LATS1	YAP1	ENSPPYP00000019136	ENSPPYP00000004354	Large tumor suppressor kinase 1.	YAP1 isoform 2.	0.998
LATS2	AJUBA	ENSPPYP00000005920	ENSPPYP00000006424	Non-specific serine/threonine protein kinase.	LIM domain-containing protein ajuba isoform X1.	0.967
LATS2	LATS1	ENSPPYP00000005920	ENSPPYP00000019136	Non-specific serine/threonine protein kinase.	Large tumor suppressor kinase 1.	0.991
LATS2	MOB1A	ENSPPYP00000005920	ENSPPYP00000013698	Non-specific serine/threonine protein kinase.	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	0.980
LATS2	MOB1B	ENSPPYP00000005920	ENSPPYP00000016542	Non-specific serine/threonine protein kinase.	MOB kinase activator 1B.	0.981
LATS2	NF2	ENSPPYP00000005920	ENSPPYP00000013046	Non-specific serine/threonine protein kinase.	Neurofibromin 2.	0.961
LATS2	SAV1	ENSPPYP00000005920	ENSPPYP00000006597	Non-specific serine/threonine protein kinase.	Salvador family WW domain containing protein 1.	0.976