CDK8 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNC	CDK19	ENSPPYP00000018878	ENSPPYP00000018945	CCNC isoform 1; Belongs to the cyclin family.	Cyclin dependent kinase 19.	0.991
CCNC	CDK8	ENSPPYP00000018878	ENSPPYP00000005956	CCNC isoform 1; Belongs to the cyclin family.	Cyclin dependent kinase 8; Belongs to the protein kinase superfamily.	0.997
CCNC	MED1	ENSPPYP00000018878	ENSPPYP00000009539	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	0.994
CCNC	MED10	ENSPPYP00000018878	ENSPPYP00000017124	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).	0.994
CCNC	MED12	ENSPPYP00000018878	ENSPPYP00000022889	CCNC isoform 1; Belongs to the cyclin family.	MED12 isoform 3.	0.994
CCNC	MED13L	ENSPPYP00000018878	ENSPPYP00000005698	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.988
CCNC	MED14	ENSPPYP00000018878	ENSPPYP00000022666	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.995
CCNC	MED18	ENSPPYP00000018878	ENSPPYP00000001898	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.991
CCNC	MED30	ENSPPYP00000018878	ENSPPYP00000021132	CCNC isoform 1; Belongs to the cyclin family.	Mediator complex subunit 30.	0.982
CCNC	MED6	ENSPPYP00000018878	ENSPPYP00000006770	CCNC isoform 1; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).	0.994
CDK19	CCNC	ENSPPYP00000018945	ENSPPYP00000018878	Cyclin dependent kinase 19.	CCNC isoform 1; Belongs to the cyclin family.	0.991
CDK19	CDK8	ENSPPYP00000018945	ENSPPYP00000005956	Cyclin dependent kinase 19.	Cyclin dependent kinase 8; Belongs to the protein kinase superfamily.	0.997
CDK19	MED1	ENSPPYP00000018945	ENSPPYP00000009539	Cyclin dependent kinase 19.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	0.980
CDK19	MED10	ENSPPYP00000018945	ENSPPYP00000017124	Cyclin dependent kinase 19.	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).	0.974
CDK19	MED12	ENSPPYP00000018945	ENSPPYP00000022889	Cyclin dependent kinase 19.	MED12 isoform 3.	0.976
CDK19	MED13L	ENSPPYP00000018945	ENSPPYP00000005698	Cyclin dependent kinase 19.	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.976
CDK19	MED14	ENSPPYP00000018945	ENSPPYP00000022666	Cyclin dependent kinase 19.	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.984
CDK19	MED18	ENSPPYP00000018945	ENSPPYP00000001898	Cyclin dependent kinase 19.	Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.971
CDK19	MED30	ENSPPYP00000018945	ENSPPYP00000021132	Cyclin dependent kinase 19.	Mediator complex subunit 30.	0.980
CDK19	MED6	ENSPPYP00000018945	ENSPPYP00000006770	Cyclin dependent kinase 19.	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).	0.982