PDS5B protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PDS5B

PDS5 cohesin associated factor B. (1447 aa)

Predicted Functional Partners:

PDS5A

0.997

SMC3

0.988

WAPL

0.987

SMC1A

0.982

RAD21

0.973

STAG2

0.968

NIPBL

0.963

SMC1B

0.929

CDCA5

0.918

CRLS1

0.901

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDCA5	NIPBL	ENSPPYP00000003568	ENSPPYP00000017209	CDCA5 isoform 4.	Nipped-B protein.	0.485
CDCA5	PDS5A	ENSPPYP00000003568	ENSPPYP00000016401	CDCA5 isoform 4.	PDS5 cohesin associated factor A.	0.940
CDCA5	PDS5B	ENSPPYP00000003568	ENSPPYP00000006002	CDCA5 isoform 4.	PDS5 cohesin associated factor B.	0.918
CDCA5	RAD21	ENSPPYP00000003568	ENSPPYP00000021128	CDCA5 isoform 4.	RAD21 cohesin complex component.	0.960
CDCA5	SMC1A	ENSPPYP00000003568	ENSPPYP00000022806	CDCA5 isoform 4.	Structural maintenance of chromosomes protein.	0.955
CDCA5	SMC1B	ENSPPYP00000003568	ENSPPYP00000013319	CDCA5 isoform 4.	Structural maintenance of chromosomes protein.	0.868
CDCA5	SMC3	ENSPPYP00000003568	ENSPPYP00000003081	CDCA5 isoform 4.	Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity); Belongs to the SMC family. SMC3 [...]	0.984
CDCA5	STAG2	ENSPPYP00000003568	ENSPPYP00000023168	CDCA5 isoform 4.	STAG2 isoform 10.	0.953
CDCA5	WAPL	ENSPPYP00000003568	ENSPPYP00000023598	CDCA5 isoform 4.	WAPL isoform 2.	0.964
CRLS1	PDS5A	ENSPPYP00000011954	ENSPPYP00000016401	CRLS1 isoform 1.	PDS5 cohesin associated factor A.	0.927
CRLS1	PDS5B	ENSPPYP00000011954	ENSPPYP00000006002	CRLS1 isoform 1.	PDS5 cohesin associated factor B.	0.901
NIPBL	CDCA5	ENSPPYP00000017209	ENSPPYP00000003568	Nipped-B protein.	CDCA5 isoform 4.	0.485
NIPBL	PDS5A	ENSPPYP00000017209	ENSPPYP00000016401	Nipped-B protein.	PDS5 cohesin associated factor A.	0.962
NIPBL	PDS5B	ENSPPYP00000017209	ENSPPYP00000006002	Nipped-B protein.	PDS5 cohesin associated factor B.	0.963
NIPBL	RAD21	ENSPPYP00000017209	ENSPPYP00000021128	Nipped-B protein.	RAD21 cohesin complex component.	0.972
NIPBL	SMC1A	ENSPPYP00000017209	ENSPPYP00000022806	Nipped-B protein.	Structural maintenance of chromosomes protein.	0.986
NIPBL	SMC1B	ENSPPYP00000017209	ENSPPYP00000013319	Nipped-B protein.	Structural maintenance of chromosomes protein.	0.933
NIPBL	SMC3	ENSPPYP00000017209	ENSPPYP00000003081	Nipped-B protein.	Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity); Belongs to the SMC family. SMC3 [...]	0.995
NIPBL	STAG2	ENSPPYP00000017209	ENSPPYP00000023168	Nipped-B protein.	STAG2 isoform 10.	0.965
NIPBL	WAPL	ENSPPYP00000017209	ENSPPYP00000023598	Nipped-B protein.	WAPL isoform 2.	0.918