| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCNA2 | CCND1 | ENSPPYP00000016798 | ENSPPYP00000003434 | CCNA2 isoform 1; Belongs to the cyclin family. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.449 |
| CCNA2 | CCNE1 | ENSPPYP00000016798 | ENSPPYP00000010983 | CCNA2 isoform 1; Belongs to the cyclin family. | CCNE1 isoform 1; Belongs to the cyclin family. | 0.784 |
| CCNA2 | CDK2 | ENSPPYP00000016798 | ENSPPYP00000005283 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
| CCNA2 | CDK4 | ENSPPYP00000016798 | ENSPPYP00000005360 | CCNA2 isoform 1; Belongs to the cyclin family. | CDK4 isoform 2; Belongs to the protein kinase superfamily. | 0.986 |
| CCNA2 | CDK6 | ENSPPYP00000016798 | ENSPPYP00000019970 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. | 0.984 |
| CCNA2 | E2F1 | ENSPPYP00000016798 | ENSPPYP00000012205 | CCNA2 isoform 1; Belongs to the cyclin family. | E2F1 isoform 1. | 0.996 |
| CCNA2 | E2F2 | ENSPPYP00000016798 | ENSPPYP00000002014 | CCNA2 isoform 1; Belongs to the cyclin family. | E2F2 isoform 1. | 0.972 |
| CCNA2 | E2F3 | ENSPPYP00000016798 | ENSPPYP00000018193 | CCNA2 isoform 1; Belongs to the cyclin family. | E2F3 isoform 2. | 0.970 |
| CCNA2 | RB1 | ENSPPYP00000016798 | ENSPPYP00000006102 | CCNA2 isoform 1; Belongs to the cyclin family. | RB1 isoform 1. | 0.998 |
| CCNA2 | SKP2 | ENSPPYP00000016798 | ENSPPYP00000017203 | CCNA2 isoform 1; Belongs to the cyclin family. | SKP2 isoform 1. | 0.983 |
| CCND1 | CCNA2 | ENSPPYP00000003434 | ENSPPYP00000016798 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | CCNA2 isoform 1; Belongs to the cyclin family. | 0.449 |
| CCND1 | CCNE1 | ENSPPYP00000003434 | ENSPPYP00000010983 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | CCNE1 isoform 1; Belongs to the cyclin family. | 0.697 |
| CCND1 | CDK2 | ENSPPYP00000003434 | ENSPPYP00000005283 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.997 |
| CCND1 | CDK4 | ENSPPYP00000003434 | ENSPPYP00000005360 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | CDK4 isoform 2; Belongs to the protein kinase superfamily. | 0.999 |
| CCND1 | CDK6 | ENSPPYP00000003434 | ENSPPYP00000019970 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. | 0.999 |
| CCND1 | E2F1 | ENSPPYP00000003434 | ENSPPYP00000012205 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | E2F1 isoform 1. | 0.813 |
| CCND1 | E2F2 | ENSPPYP00000003434 | ENSPPYP00000002014 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | E2F2 isoform 1. | 0.629 |
| CCND1 | E2F3 | ENSPPYP00000003434 | ENSPPYP00000018193 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | E2F3 isoform 2. | 0.697 |
| CCND1 | RB1 | ENSPPYP00000003434 | ENSPPYP00000006102 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | RB1 isoform 1. | 0.998 |
| CCND1 | SKP2 | ENSPPYP00000003434 | ENSPPYP00000017203 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | SKP2 isoform 1. | 0.917 |
