Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DIS3DIS3 isoform 1; Belongs to the RNR ribonuclease family. (957 aa)    
Predicted Functional Partners:
EXOSC1
Exosome component 1.
   
 0.998
EXOSC3
Exosome component 3.
   
 0.998
EXOSC2
EXOSC2 isoform 3.
   
 0.998
EXOSC9
Exosome component 9.
   
 0.996
EXOSC10
EXOSC10 isoform 2.
   
 0.995
EXOSC8
Exosome component 8.
   
 0.995
EXOSC7
EXOSC7 isoform 6.
   
 0.993
EXOSC4
EXOSC4 isoform 1.
   
 0.993
EXOSC5
EXOSC5 isoform 1.
   
 0.991
MTREX
SKIV2L2 isoform 1.
   
 0.975
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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