ENSPPYP00000006214 protein (Pongo abelii) - STRING interaction network

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Predicted Interactions

gene neighborhood

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protein homology

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Score

ENSPPYP00000006214

annotation not available (312 aa)

Predicted Functional Partners:

STIP1

0.815

PTGES3

0.792

AIP

0.767

PPID

0.731

FKBP5

0.726

SUGT1

0.714

ENSPPYP00000001359

0.712

NR3C1

0.694

TSC2

0.689

STUB1

0.685

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIP	ENSPPYP00000001359	ENSPPYP00000003465	ENSPPYP00000001359	Peptidylprolyl isomerase.	annotation not available	0.701
AIP	ENSPPYP00000006214	ENSPPYP00000003465	ENSPPYP00000006214	Peptidylprolyl isomerase.	annotation not available	0.767
AIP	PTGES3	ENSPPYP00000003465	ENSPPYP00000005319	Peptidylprolyl isomerase.	Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.	0.835
ENSPPYP00000001359	AIP	ENSPPYP00000001359	ENSPPYP00000003465	annotation not available	Peptidylprolyl isomerase.	0.701
ENSPPYP00000001359	ENSPPYP00000006214	ENSPPYP00000001359	ENSPPYP00000006214	annotation not available	annotation not available	0.712
ENSPPYP00000001359	FKBP5	ENSPPYP00000001359	ENSPPYP00000018489	annotation not available	Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity).	0.726
ENSPPYP00000001359	NR3C1	ENSPPYP00000001359	ENSPPYP00000017784	annotation not available	Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...]	0.864
ENSPPYP00000001359	PPID	ENSPPYP00000001359	ENSPPYP00000016942	annotation not available	Peptidylprolyl isomerase D.	0.792
ENSPPYP00000001359	STIP1	ENSPPYP00000001359	ENSPPYP00000003602	annotation not available	STIP1 isoform 2.	0.872
ENSPPYP00000006214	AIP	ENSPPYP00000006214	ENSPPYP00000003465	annotation not available	Peptidylprolyl isomerase.	0.767
ENSPPYP00000006214	ENSPPYP00000001359	ENSPPYP00000006214	ENSPPYP00000001359	annotation not available	annotation not available	0.712
ENSPPYP00000006214	FKBP5	ENSPPYP00000006214	ENSPPYP00000018489	annotation not available	Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity).	0.726
ENSPPYP00000006214	NR3C1	ENSPPYP00000006214	ENSPPYP00000017784	annotation not available	Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...]	0.694
ENSPPYP00000006214	PPID	ENSPPYP00000006214	ENSPPYP00000016942	annotation not available	Peptidylprolyl isomerase D.	0.731
ENSPPYP00000006214	PTGES3	ENSPPYP00000006214	ENSPPYP00000005319	annotation not available	Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.	0.792
ENSPPYP00000006214	STIP1	ENSPPYP00000006214	ENSPPYP00000003602	annotation not available	STIP1 isoform 2.	0.815
ENSPPYP00000006214	STUB1	ENSPPYP00000006214	ENSPPYP00000007837	annotation not available	STIP1 homology and U-box containing protein 1.	0.685
ENSPPYP00000006214	SUGT1	ENSPPYP00000006214	ENSPPYP00000006144	annotation not available	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.714
ENSPPYP00000006214	TSC2	ENSPPYP00000006214	ENSPPYP00000007907	annotation not available	TSC2 isoform 1.	0.689
FKBP5	ENSPPYP00000001359	ENSPPYP00000018489	ENSPPYP00000001359	Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity).	annotation not available	0.726