Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
UBAC2UBAC2 isoform 5. (392 aa)    
Predicted Functional Partners:
FAF2
Fas associated factor family member 2.
    
 
 0.946
NPLOC4
NPLOC4 isoform 1.
    
 
 0.932
UFD1
Ubiquitin recognition factor in ER associated degradation 1.
    
 
 0.925
AMFR
AMFR isoform 1.
    
 
 0.865
EMC3
ER membrane protein complex subunit 3; Belongs to the EMC3 family.
   
 
 0.854
EMC1
ER membrane protein complex subunit 1; Belongs to the EMC1 family.
    
 
 0.836
SYVN1
SYVN1 isoform 3.
    
 
 0.828
EMC2
ER membrane protein complex subunit 2; Belongs to the EMC2 family.
    
 
 0.807
UBXN8
UBXN8 isoform 1.
    
 
 0.802
ERLIN1
Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity).
    
 
 0.776
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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