| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC73 | CTR9 | ENSPPYP00000000447 | ENSPPYP00000004001 | Cell division cycle 73. | CTR9 isoform 1. | 0.999 |
| CDC73 | IWS1 | ENSPPYP00000000447 | ENSPPYP00000023972 | Cell division cycle 73. | Interacts with SUPT6H, CTD assembly factor 1. | 0.680 |
| CDC73 | LEO1 | ENSPPYP00000000447 | ENSPPYP00000007344 | Cell division cycle 73. | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...] | 0.999 |
| CDC73 | POLR2B | ENSPPYP00000000447 | ENSPPYP00000016468 | Cell division cycle 73. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.857 |
| CDC73 | POLR2C | ENSPPYP00000000447 | ENSPPYP00000008349 | Cell division cycle 73. | RNA polymerase II subunit C. | 0.794 |
| CDC73 | SSRP1 | ENSPPYP00000000447 | ENSPPYP00000024077 | Cell division cycle 73. | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.940 |
| CDC73 | SUPT16H | ENSPPYP00000000447 | ENSPPYP00000006363 | Cell division cycle 73. | SPT16 homolog, facilitates chromatin remodeling subunit. | 0.950 |
| CDC73 | SUPT4H1 | ENSPPYP00000000447 | ENSPPYP00000009251 | Cell division cycle 73. | Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] | 0.905 |
| CDC73 | SUPT5H | ENSPPYP00000000447 | ENSPPYP00000011160 | Cell division cycle 73. | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] | 0.903 |
| CDC73 | SUPT6H | ENSPPYP00000000447 | ENSPPYP00000009113 | Cell division cycle 73. | Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. | 0.888 |
| CTR9 | CDC73 | ENSPPYP00000004001 | ENSPPYP00000000447 | CTR9 isoform 1. | Cell division cycle 73. | 0.999 |
| CTR9 | IWS1 | ENSPPYP00000004001 | ENSPPYP00000023972 | CTR9 isoform 1. | Interacts with SUPT6H, CTD assembly factor 1. | 0.914 |
| CTR9 | LEO1 | ENSPPYP00000004001 | ENSPPYP00000007344 | CTR9 isoform 1. | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...] | 0.999 |
| CTR9 | POLR2B | ENSPPYP00000004001 | ENSPPYP00000016468 | CTR9 isoform 1. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.710 |
| CTR9 | POLR2C | ENSPPYP00000004001 | ENSPPYP00000008349 | CTR9 isoform 1. | RNA polymerase II subunit C. | 0.854 |
| CTR9 | SSRP1 | ENSPPYP00000004001 | ENSPPYP00000024077 | CTR9 isoform 1. | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.954 |
| CTR9 | SUPT16H | ENSPPYP00000004001 | ENSPPYP00000006363 | CTR9 isoform 1. | SPT16 homolog, facilitates chromatin remodeling subunit. | 0.963 |
| CTR9 | SUPT4H1 | ENSPPYP00000004001 | ENSPPYP00000009251 | CTR9 isoform 1. | Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] | 0.880 |
| CTR9 | SUPT5H | ENSPPYP00000004001 | ENSPPYP00000011160 | CTR9 isoform 1. | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] | 0.900 |
| CTR9 | SUPT6H | ENSPPYP00000004001 | ENSPPYP00000009113 | CTR9 isoform 1. | Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. | 0.921 |
