| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDKL1 | CDKL2 | ENSPPYP00000006593 | ENSPPYP00000016576 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | Cyclin-dependent kinase-like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.845 |
| CDKL1 | CDKL3 | ENSPPYP00000006593 | ENSPPYP00000017651 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | CDKL3 isoform 6. | 0.931 |
| CDKL1 | FKBP5 | ENSPPYP00000006593 | ENSPPYP00000018489 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity). | 0.594 |
| CDKL1 | MCL1 | ENSPPYP00000006593 | ENSPPYP00000001046 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | MCL1 apoptosis regulator, BCL2 family member. | 0.580 |
| CDKL1 | PCDHB1 | ENSPPYP00000006593 | ENSPPYP00000017757 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | PCDHB1 isoform 1. | 0.509 |
| CDKL1 | SIRT1 | ENSPPYP00000006593 | ENSPPYP00000002788 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | SIRT1 isoform 1. | 0.646 |
| CDKL1 | SPHKAP | ENSPPYP00000006593 | ENSPPYP00000014806 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | SPHKAP isoform 1. | 0.499 |
| CDKL1 | TCTN1 | ENSPPYP00000006593 | ENSPPYP00000005652 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | TCTN1 isoform 1. | 0.507 |
| CDKL1 | YWHAB | ENSPPYP00000006593 | ENSPPYP00000012330 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.732 |
| CDKL1 | YWHAG | ENSPPYP00000006593 | ENSPPYP00000019583 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | 14-3-3 protein gamma, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family. | 0.546 |
| CDKL2 | CDKL1 | ENSPPYP00000016576 | ENSPPYP00000006593 | Cyclin-dependent kinase-like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | 0.845 |
| CDKL2 | CDKL3 | ENSPPYP00000016576 | ENSPPYP00000017651 | Cyclin-dependent kinase-like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | CDKL3 isoform 6. | 0.860 |
| CDKL3 | CDKL1 | ENSPPYP00000017651 | ENSPPYP00000006593 | CDKL3 isoform 6. | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | 0.931 |
| CDKL3 | CDKL2 | ENSPPYP00000017651 | ENSPPYP00000016576 | CDKL3 isoform 6. | Cyclin-dependent kinase-like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.860 |
| FKBP5 | CDKL1 | ENSPPYP00000018489 | ENSPPYP00000006593 | Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity). | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | 0.594 |
| MCL1 | CDKL1 | ENSPPYP00000001046 | ENSPPYP00000006593 | MCL1 apoptosis regulator, BCL2 family member. | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | 0.580 |
| MCL1 | YWHAB | ENSPPYP00000001046 | ENSPPYP00000012330 | MCL1 apoptosis regulator, BCL2 family member. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.616 |
| MCL1 | YWHAG | ENSPPYP00000001046 | ENSPPYP00000019583 | MCL1 apoptosis regulator, BCL2 family member. | 14-3-3 protein gamma, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family. | 0.492 |
| PCDHB1 | CDKL1 | ENSPPYP00000017757 | ENSPPYP00000006593 | PCDHB1 isoform 1. | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | 0.509 |
| SIRT1 | CDKL1 | ENSPPYP00000002788 | ENSPPYP00000006593 | SIRT1 isoform 1. | CDKL1 isoform 1; Belongs to the protein kinase superfamily. | 0.646 |
