| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0010096 | FAXDC2 | ENSPPYP00000019975 | ENSPPYP00000017878 | LRRD1 isoform 1. | Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. | 0.487 |
| CR201_G0010096 | STYX | ENSPPYP00000019975 | ENSPPYP00000006613 | LRRD1 isoform 1. | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.515 |
| DDHD1 | GPR137C | ENSPPYP00000006619 | ENSPPYP00000023719 | DDHD1 isoform 3. | GPR137C isoform 1. | 0.471 |
| DDHD1 | STYX | ENSPPYP00000006619 | ENSPPYP00000006613 | DDHD1 isoform 3. | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.487 |
| DDHD1 | TXNDC16 | ENSPPYP00000006619 | ENSPPYP00000006610 | DDHD1 isoform 3. | TXNDC16 isoform 1. | 0.510 |
| FAXDC2 | CR201_G0010096 | ENSPPYP00000017878 | ENSPPYP00000019975 | Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. | LRRD1 isoform 1. | 0.487 |
| FAXDC2 | SHOC2 | ENSPPYP00000017878 | ENSPPYP00000003088 | Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. | Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. | 0.657 |
| FAXDC2 | STYX | ENSPPYP00000017878 | ENSPPYP00000006613 | Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.724 |
| FBXO38 | STYX | ENSPPYP00000017817 | ENSPPYP00000006613 | FBXO38 isoform 1. | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.581 |
| FBXW7 | STYX | ENSPPYP00000016901 | ENSPPYP00000006613 | FBXW7 isoform 8. | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.799 |
| FBXW9 | STYX | ENSPPYP00000010765 | ENSPPYP00000006613 | F-box and WD repeat domain containing 9. | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.583 |
| GNPNAT1 | STYX | ENSPPYP00000006615 | ENSPPYP00000006613 | Glucosamine 6-phosphate N-acetyltransferase. | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.603 |
| GPR137C | DDHD1 | ENSPPYP00000023719 | ENSPPYP00000006619 | GPR137C isoform 1. | DDHD1 isoform 3. | 0.471 |
| GPR137C | STYX | ENSPPYP00000023719 | ENSPPYP00000006613 | GPR137C isoform 1. | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.512 |
| GPR137C | TXNDC16 | ENSPPYP00000023719 | ENSPPYP00000006610 | GPR137C isoform 1. | TXNDC16 isoform 1. | 0.569 |
| SHOC2 | FAXDC2 | ENSPPYP00000003088 | ENSPPYP00000017878 | Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. | Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. | 0.657 |
| SHOC2 | STYX | ENSPPYP00000003088 | ENSPPYP00000006613 | Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.674 |
| STYX | CR201_G0010096 | ENSPPYP00000006613 | ENSPPYP00000019975 | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | LRRD1 isoform 1. | 0.515 |
| STYX | DDHD1 | ENSPPYP00000006613 | ENSPPYP00000006619 | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | DDHD1 isoform 3. | 0.487 |
| STYX | FAXDC2 | ENSPPYP00000006613 | ENSPPYP00000017878 | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. | 0.724 |
