STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIX4SIX4 isoform 1. (698 aa)    
Predicted Functional Partners:
EYA2
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 
 0.806
EYA1
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 
 0.731
BHLHE40
Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK- ARNTL/BMAL1|ARNTL2/ [...]
      
 0.641
TNNT3
TNNT3 isoform 14.
   
  
 0.638
LRRC17
LRRC17 isoform 2.
    
 
 0.638
EYA4
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 
 0.631
EYA3
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 
 0.629
DACT1
Dishevelled binding antagonist of beta catenin 1.
      
 0.580
FOSL2
FOS like 2, AP-1 transcription factor subunit.
      
 0.577
KDM6A
UTY isoform 5.
    
 
 0.573
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.