| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BHLHE40 | SIX4 | ENSPPYP00000015316 | ENSPPYP00000006677 | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK- ARNTL/BMAL1|ARNTL2/ [...] | SIX4 isoform 1. | 0.528 |
| EMX2 | PAX2 | ENSPPYP00000003284 | ENSPPYP00000002985 | EMX2 isoform 1. | PAX2 isoform 3. | 0.757 |
| EMX2 | PAX5 | ENSPPYP00000003284 | ENSPPYP00000021364 | EMX2 isoform 1. | PAX5 isoform 1. | 0.548 |
| EMX2 | PAX8 | ENSPPYP00000003284 | ENSPPYP00000013583 | EMX2 isoform 1. | Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity). | 0.546 |
| EMX2 | SIX4 | ENSPPYP00000003284 | ENSPPYP00000006677 | EMX2 isoform 1. | SIX4 isoform 1. | 0.569 |
| EYA1 | EYA2 | ENSPPYP00000020937 | ENSPPYP00000012403 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | 0.553 |
| EYA1 | EYA3 | ENSPPYP00000020937 | ENSPPYP00000001904 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | 0.406 |
| EYA1 | PAX2 | ENSPPYP00000020937 | ENSPPYP00000002985 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | PAX2 isoform 3. | 0.819 |
| EYA1 | PAX5 | ENSPPYP00000020937 | ENSPPYP00000021364 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | PAX5 isoform 1. | 0.699 |
| EYA1 | PAX8 | ENSPPYP00000020937 | ENSPPYP00000013583 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity). | 0.770 |
| EYA1 | SIX4 | ENSPPYP00000020937 | ENSPPYP00000006677 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | SIX4 isoform 1. | 0.723 |
| EYA1 | TNNT3 | ENSPPYP00000020937 | ENSPPYP00000003388 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | TNNT3 isoform 14. | 0.532 |
| EYA2 | EYA1 | ENSPPYP00000012403 | ENSPPYP00000020937 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | 0.553 |
| EYA2 | EYA3 | ENSPPYP00000012403 | ENSPPYP00000001904 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | 0.415 |
| EYA2 | EYA4 | ENSPPYP00000012403 | ENSPPYP00000019059 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | 0.553 |
| EYA2 | SIX4 | ENSPPYP00000012403 | ENSPPYP00000006677 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | SIX4 isoform 1. | 0.767 |
| EYA3 | EYA1 | ENSPPYP00000001904 | ENSPPYP00000020937 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | 0.406 |
| EYA3 | EYA2 | ENSPPYP00000001904 | ENSPPYP00000012403 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | 0.415 |
| EYA3 | SIX4 | ENSPPYP00000001904 | ENSPPYP00000006677 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | SIX4 isoform 1. | 0.715 |
| EYA4 | EYA2 | ENSPPYP00000019059 | ENSPPYP00000012403 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. | 0.553 |
