| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0025573 | ITSN2 | ENSPPYP00000002299 | ENSPPYP00000014069 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | ITSN2 isoform 3. | 0.413 |
| CR201_G0025573 | PARD6B | ENSPPYP00000002299 | ENSPPYP00000012435 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Par-6 family cell polarity regulator beta. | 0.981 |
| CR201_G0025573 | PRKCI | ENSPPYP00000002299 | ENSPPYP00000015972 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...] | 0.915 |
| CR201_G0025573 | RHOJ | ENSPPYP00000002299 | ENSPPYP00000006693 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Ras homolog family member J. | 0.757 |
| CR201_G0025573 | RHOQ | ENSPPYP00000002299 | ENSPPYP00000013889 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | RHOQ isoform 1. | 0.531 |
| DOCK8 | RHOJ | ENSPPYP00000021575 | ENSPPYP00000006693 | DOCK8 isoform 2; Belongs to the DOCK family. | Ras homolog family member J. | 0.855 |
| DOCK8 | RHOQ | ENSPPYP00000021575 | ENSPPYP00000013889 | DOCK8 isoform 2; Belongs to the DOCK family. | RHOQ isoform 1. | 0.807 |
| ITSN1 | ITSN2 | ENSPPYP00000012707 | ENSPPYP00000014069 | ITSN1 isoform 4. | ITSN2 isoform 3. | 0.838 |
| ITSN1 | PAK6 | ENSPPYP00000012707 | ENSPPYP00000007186 | ITSN1 isoform 4. | Serine/threonine-protein kinase PAK 6; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR- mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity); Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase fam [...] | 0.432 |
| ITSN1 | RHOJ | ENSPPYP00000012707 | ENSPPYP00000006693 | ITSN1 isoform 4. | Ras homolog family member J. | 0.746 |
| ITSN1 | RHOQ | ENSPPYP00000012707 | ENSPPYP00000013889 | ITSN1 isoform 4. | RHOQ isoform 1. | 0.829 |
| ITSN2 | CR201_G0025573 | ENSPPYP00000014069 | ENSPPYP00000002299 | ITSN2 isoform 3. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.413 |
| ITSN2 | ITSN1 | ENSPPYP00000014069 | ENSPPYP00000012707 | ITSN2 isoform 3. | ITSN1 isoform 4. | 0.838 |
| ITSN2 | PAK1 | ENSPPYP00000014069 | ENSPPYP00000004237 | ITSN2 isoform 3. | Non-specific serine/threonine protein kinase. | 0.475 |
| ITSN2 | PAK2 | ENSPPYP00000014069 | ENSPPYP00000016156 | ITSN2 isoform 3. | Non-specific serine/threonine protein kinase. | 0.476 |
| ITSN2 | PAK6 | ENSPPYP00000014069 | ENSPPYP00000007186 | ITSN2 isoform 3. | Serine/threonine-protein kinase PAK 6; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR- mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity); Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase fam [...] | 0.475 |
| ITSN2 | PRKCI | ENSPPYP00000014069 | ENSPPYP00000015972 | ITSN2 isoform 3. | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...] | 0.413 |
| ITSN2 | RHOJ | ENSPPYP00000014069 | ENSPPYP00000006693 | ITSN2 isoform 3. | Ras homolog family member J. | 0.865 |
| ITSN2 | RHOQ | ENSPPYP00000014069 | ENSPPYP00000013889 | ITSN2 isoform 3. | RHOQ isoform 1. | 0.865 |
| PAK1 | ITSN2 | ENSPPYP00000004237 | ENSPPYP00000014069 | Non-specific serine/threonine protein kinase. | ITSN2 isoform 3. | 0.475 |
