| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADD2 | CR201_G0009827 | ENSPPYP00000013740 | ENSPPYP00000006712 | Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Belongs to the aldolase class II family. Adducin subfamily. | Spectrin beta chain; Belongs to the spectrin family. | 0.816 |
| ADD2 | CR201_G0015864 | ENSPPYP00000013740 | ENSPPYP00000001882 | Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Belongs to the aldolase class II family. Adducin subfamily. | EPB41 isoform 1. | 0.576 |
| ADD2 | DMTN | ENSPPYP00000013740 | ENSPPYP00000020629 | Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Belongs to the aldolase class II family. Adducin subfamily. | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] | 0.977 |
| ADD2 | SLC4A1 | ENSPPYP00000013740 | ENSPPYP00000009373 | Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Belongs to the aldolase class II family. Adducin subfamily. | Anion exchange protein. | 0.610 |
| ADD2 | SPTA1 | ENSPPYP00000013740 | ENSPPYP00000000783 | Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Belongs to the aldolase class II family. Adducin subfamily. | SPTA1 isoform 1. | 0.626 |
| ADD2 | SPTAN1 | ENSPPYP00000013740 | ENSPPYP00000022030 | Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Belongs to the aldolase class II family. Adducin subfamily. | SPTAN1 isoform 10. | 0.581 |
| ANK1 | CR201_G0009827 | ENSPPYP00000020798 | ENSPPYP00000006712 | Ankyrin-1 isoform X1. | Spectrin beta chain; Belongs to the spectrin family. | 0.969 |
| ANK1 | CR201_G0015864 | ENSPPYP00000020798 | ENSPPYP00000001882 | Ankyrin-1 isoform X1. | EPB41 isoform 1. | 0.569 |
| ANK1 | DMTN | ENSPPYP00000020798 | ENSPPYP00000020629 | Ankyrin-1 isoform X1. | Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] | 0.467 |
| ANK1 | EPB42 | ENSPPYP00000020798 | ENSPPYP00000007260 | Ankyrin-1 isoform X1. | EPB42 isoform 1. | 0.728 |
| ANK1 | SLC4A1 | ENSPPYP00000020798 | ENSPPYP00000009373 | Ankyrin-1 isoform X1. | Anion exchange protein. | 0.924 |
| ANK1 | SPTA1 | ENSPPYP00000020798 | ENSPPYP00000000783 | Ankyrin-1 isoform X1. | SPTA1 isoform 1. | 0.974 |
| ANK1 | SPTAN1 | ENSPPYP00000020798 | ENSPPYP00000022030 | Ankyrin-1 isoform X1. | SPTAN1 isoform 10. | 0.631 |
| ANK2 | ANK3 | ENSPPYP00000016765 | ENSPPYP00000002809 | ANK2 isoform 1. | ANK3 isoform 1. | 0.441 |
| ANK2 | CR201_G0009827 | ENSPPYP00000016765 | ENSPPYP00000006712 | ANK2 isoform 1. | Spectrin beta chain; Belongs to the spectrin family. | 0.747 |
| ANK2 | SLC4A1 | ENSPPYP00000016765 | ENSPPYP00000009373 | ANK2 isoform 1. | Anion exchange protein. | 0.472 |
| ANK2 | SPTA1 | ENSPPYP00000016765 | ENSPPYP00000000783 | ANK2 isoform 1. | SPTA1 isoform 1. | 0.587 |
| ANK2 | SPTAN1 | ENSPPYP00000016765 | ENSPPYP00000022030 | ANK2 isoform 1. | SPTAN1 isoform 10. | 0.705 |
| ANK3 | ANK2 | ENSPPYP00000002809 | ENSPPYP00000016765 | ANK3 isoform 1. | ANK2 isoform 1. | 0.441 |
| ANK3 | CR201_G0009827 | ENSPPYP00000002809 | ENSPPYP00000006712 | ANK3 isoform 1. | Spectrin beta chain; Belongs to the spectrin family. | 0.717 |
