node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP6V0A1 | ATP6V0C | ENSPPYP00000009433 | ENSPPYP00000007925 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type H+-transporting ATPase 16kDa proteolipid subunit. | 0.998 |
ATP6V0A1 | ATP6V0D1 | ENSPPYP00000009433 | ENSPPYP00000008426 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...] | 0.997 |
ATP6V0A1 | ATP6V1A | ENSPPYP00000009433 | ENSPPYP00000015134 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. | 0.995 |
ATP6V0A1 | ATP6V1B1 | ENSPPYP00000009433 | ENSPPYP00000013735 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit B, brain isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). | 0.991 |
ATP6V0A1 | ATP6V1B2 | ENSPPYP00000009433 | ENSPPYP00000020619 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit B, brain isoform. | 0.977 |
ATP6V0A1 | ATP6V1C1 | ENSPPYP00000009433 | ENSPPYP00000021093 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit C 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). | 0.989 |
ATP6V0A1 | ATP6V1D | ENSPPYP00000009433 | ENSPPYP00000006728 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). | 0.993 |
ATP6V0A1 | ATP6V1E1 | ENSPPYP00000009433 | ENSPPYP00000012897 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | ATP6V1E1 isoform 1. | 0.983 |
ATP6V0A1 | ATP6V1F | ENSPPYP00000009433 | ENSPPYP00000020179 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. | 0.989 |
ATP6V0A1 | ATP6V1H | ENSPPYP00000009433 | ENSPPYP00000020844 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. | 0.996 |
ATP6V0C | ATP6V0A1 | ENSPPYP00000007925 | ENSPPYP00000009433 | V-type H+-transporting ATPase 16kDa proteolipid subunit. | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | 0.998 |
ATP6V0C | ATP6V0D1 | ENSPPYP00000007925 | ENSPPYP00000008426 | V-type H+-transporting ATPase 16kDa proteolipid subunit. | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...] | 0.998 |
ATP6V0C | ATP6V1A | ENSPPYP00000007925 | ENSPPYP00000015134 | V-type H+-transporting ATPase 16kDa proteolipid subunit. | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. | 0.996 |
ATP6V0C | ATP6V1B1 | ENSPPYP00000007925 | ENSPPYP00000013735 | V-type H+-transporting ATPase 16kDa proteolipid subunit. | V-type proton ATPase subunit B, brain isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). | 0.983 |
ATP6V0C | ATP6V1B2 | ENSPPYP00000007925 | ENSPPYP00000020619 | V-type H+-transporting ATPase 16kDa proteolipid subunit. | V-type proton ATPase subunit B, brain isoform. | 0.993 |
ATP6V0C | ATP6V1C1 | ENSPPYP00000007925 | ENSPPYP00000021093 | V-type H+-transporting ATPase 16kDa proteolipid subunit. | V-type proton ATPase subunit C 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). | 0.987 |
ATP6V0C | ATP6V1D | ENSPPYP00000007925 | ENSPPYP00000006728 | V-type H+-transporting ATPase 16kDa proteolipid subunit. | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). | 0.993 |
ATP6V0C | ATP6V1E1 | ENSPPYP00000007925 | ENSPPYP00000012897 | V-type H+-transporting ATPase 16kDa proteolipid subunit. | ATP6V1E1 isoform 1. | 0.984 |
ATP6V0C | ATP6V1F | ENSPPYP00000007925 | ENSPPYP00000020179 | V-type H+-transporting ATPase 16kDa proteolipid subunit. | V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. | 0.994 |
ATP6V0C | ATP6V1H | ENSPPYP00000007925 | ENSPPYP00000020844 | V-type H+-transporting ATPase 16kDa proteolipid subunit. | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. | 0.997 |