| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0029663 | DPYSL2 | ENSPPYP00000011487 | ENSPPYP00000020686 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | 0.493 |
| CR201_G0029663 | EPS15 | ENSPPYP00000011487 | ENSPPYP00000001582 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Epidermal growth factor receptor pathway substrate 15. | 0.985 |
| CR201_G0029663 | NUMB | ENSPPYP00000011487 | ENSPPYP00000006785 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | NUMB endocytic adaptor protein. | 0.878 |
| CR201_G0029663 | NUMBL | ENSPPYP00000011487 | ENSPPYP00000011192 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | NUMBL isoform 1. | 0.864 |
| DPYSL2 | CR201_G0029663 | ENSPPYP00000020686 | ENSPPYP00000011487 | Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | 0.493 |
| DPYSL2 | NUMB | ENSPPYP00000020686 | ENSPPYP00000006785 | Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | NUMB endocytic adaptor protein. | 0.833 |
| DPYSL2 | NUMBL | ENSPPYP00000020686 | ENSPPYP00000011192 | Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | NUMBL isoform 1. | 0.582 |
| EPS15 | CR201_G0029663 | ENSPPYP00000001582 | ENSPPYP00000011487 | Epidermal growth factor receptor pathway substrate 15. | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | 0.985 |
| EPS15 | NUMB | ENSPPYP00000001582 | ENSPPYP00000006785 | Epidermal growth factor receptor pathway substrate 15. | NUMB endocytic adaptor protein. | 0.833 |
| EPS15 | NUMBL | ENSPPYP00000001582 | ENSPPYP00000011192 | Epidermal growth factor receptor pathway substrate 15. | NUMBL isoform 1. | 0.779 |
| ITCH | NOTCH1 | ENSPPYP00000012212 | ENSPPYP00000022176 | E3 ubiquitin-protein ligase. | NOTCH1 isoform 1. | 0.750 |
| ITCH | NOTCH2 | ENSPPYP00000012212 | ENSPPYP00000001116 | E3 ubiquitin-protein ligase. | NOTCH2 isoform 2. | 0.934 |
| ITCH | NOTCH3 | ENSPPYP00000012212 | ENSPPYP00000010835 | E3 ubiquitin-protein ligase. | NOTCH3 isoform 1. | 0.938 |
| ITCH | NUMB | ENSPPYP00000012212 | ENSPPYP00000006785 | E3 ubiquitin-protein ligase. | NUMB endocytic adaptor protein. | 0.963 |
| ITCH | NUMBL | ENSPPYP00000012212 | ENSPPYP00000011192 | E3 ubiquitin-protein ligase. | NUMBL isoform 1. | 0.918 |
| ITCH | TP53 | ENSPPYP00000012212 | ENSPPYP00000008923 | E3 ubiquitin-protein ligase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.839 |
| LNX1 | NUMB | ENSPPYP00000016498 | ENSPPYP00000006785 | LNX1 isoform 2. | NUMB endocytic adaptor protein. | 0.914 |
| LNX1 | NUMBL | ENSPPYP00000016498 | ENSPPYP00000011192 | LNX1 isoform 2. | NUMBL isoform 1. | 0.866 |
| NOTCH1 | ITCH | ENSPPYP00000022176 | ENSPPYP00000012212 | NOTCH1 isoform 1. | E3 ubiquitin-protein ligase. | 0.750 |
| NOTCH1 | NOTCH3 | ENSPPYP00000022176 | ENSPPYP00000010835 | NOTCH1 isoform 1. | NOTCH3 isoform 1. | 0.885 |
