FOS protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESR1	ESR2	ENSPPYP00000019159	ENSPPYP00000006703	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	ESR2 isoform 12.	0.999
ESR1	FOS	ENSPPYP00000019159	ENSPPYP00000006826	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.988
ESR1	JUN	ENSPPYP00000019159	ENSPPYP00000001511	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	JUN isoform 1; Belongs to the bZIP family.	0.990
ESR1	MAPK10	ENSPPYP00000019159	ENSPPYP00000016644	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mitogen-activated protein kinase.	0.916
ESR1	MAPK14	ENSPPYP00000019159	ENSPPYP00000018500	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mitogen-activated protein kinase.	0.955
ESR1	MAPK3	ENSPPYP00000019159	ENSPPYP00000008184	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.977
ESR1	MAPK8	ENSPPYP00000019159	ENSPPYP00000002621	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mitogen-activated protein kinase.	0.921
ESR1	MAPK9	ENSPPYP00000019159	ENSPPYP00000018050	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mitogen-activated protein kinase.	0.910
ESR1	RUNX2	ENSPPYP00000019159	ENSPPYP00000018641	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.649
ESR2	ESR1	ENSPPYP00000006703	ENSPPYP00000019159	ESR2 isoform 12.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.999
ESR2	FOS	ENSPPYP00000006703	ENSPPYP00000006826	ESR2 isoform 12.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.969
ESR2	JUN	ENSPPYP00000006703	ENSPPYP00000001511	ESR2 isoform 12.	JUN isoform 1; Belongs to the bZIP family.	0.971
ESR2	MAPK10	ENSPPYP00000006703	ENSPPYP00000016644	ESR2 isoform 12.	Mitogen-activated protein kinase.	0.909
ESR2	MAPK14	ENSPPYP00000006703	ENSPPYP00000018500	ESR2 isoform 12.	Mitogen-activated protein kinase.	0.933
ESR2	MAPK3	ENSPPYP00000006703	ENSPPYP00000008184	ESR2 isoform 12.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.958
ESR2	MAPK8	ENSPPYP00000006703	ENSPPYP00000002621	ESR2 isoform 12.	Mitogen-activated protein kinase.	0.909
ESR2	MAPK9	ENSPPYP00000006703	ENSPPYP00000018050	ESR2 isoform 12.	Mitogen-activated protein kinase.	0.906
ESR2	RUNX2	ENSPPYP00000006703	ENSPPYP00000018641	ESR2 isoform 12.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.496
FOS	ESR1	ENSPPYP00000006826	ENSPPYP00000019159	Fos proto-oncogene, AP-1 transcription factor subunit.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.988
FOS	ESR2	ENSPPYP00000006826	ENSPPYP00000006703	Fos proto-oncogene, AP-1 transcription factor subunit.	ESR2 isoform 12.	0.969