SERPINA3 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	C9	ENSPPYP00000000122	ENSPPYP00000017221	AGT isoform 1; Belongs to the serpin family.	Complement C9.	0.481
AGT	F2	ENSPPYP00000000122	ENSPPYP00000003807	AGT isoform 1; Belongs to the serpin family.	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	0.669
AGT	HPX	ENSPPYP00000000122	ENSPPYP00000004063	AGT isoform 1; Belongs to the serpin family.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.403
AGT	KNG1	ENSPPYP00000000122	ENSPPYP00000016088	AGT isoform 1; Belongs to the serpin family.	KNG1 isoform 1.	0.864
AGT	ORM1	ENSPPYP00000000122	ENSPPYP00000021887	AGT isoform 1; Belongs to the serpin family.	Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Belongs to the calycin superfamily. Lipocalin family.	0.432
AGT	SERPINA3	ENSPPYP00000000122	ENSPPYP00000006946	AGT isoform 1; Belongs to the serpin family.	Alpha-1-antichymotrypsin; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.	0.851
AGT	SERPINC1	ENSPPYP00000000122	ENSPPYP00000000566	AGT isoform 1; Belongs to the serpin family.	Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).	0.571
BPIFA1	SERPINA3	ENSPPYP00000012195	ENSPPYP00000006946	BPIFA1 isoform 1.	Alpha-1-antichymotrypsin; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.	0.684
C9	AGT	ENSPPYP00000017221	ENSPPYP00000000122	Complement C9.	AGT isoform 1; Belongs to the serpin family.	0.481
C9	F2	ENSPPYP00000017221	ENSPPYP00000003807	Complement C9.	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	0.547
C9	HPX	ENSPPYP00000017221	ENSPPYP00000004063	Complement C9.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.449
C9	KNG1	ENSPPYP00000017221	ENSPPYP00000016088	Complement C9.	KNG1 isoform 1.	0.720
C9	SERPINA3	ENSPPYP00000017221	ENSPPYP00000006946	Complement C9.	Alpha-1-antichymotrypsin; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.	0.631
C9	SERPINC1	ENSPPYP00000017221	ENSPPYP00000000566	Complement C9.	Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).	0.576
F2	AGT	ENSPPYP00000003807	ENSPPYP00000000122	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	AGT isoform 1; Belongs to the serpin family.	0.669
F2	C9	ENSPPYP00000003807	ENSPPYP00000017221	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	Complement C9.	0.547
F2	HPX	ENSPPYP00000003807	ENSPPYP00000004063	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.593
F2	KNG1	ENSPPYP00000003807	ENSPPYP00000016088	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	KNG1 isoform 1.	0.866
F2	SERPINA1	ENSPPYP00000003807	ENSPPYP00000006940	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	Alpha-1-antitrypsin; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity); Belongs to the serpin family.	0.643
F2	SERPINA2	ENSPPYP00000003807	ENSPPYP00000006938	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	SERPINA2 isoform 1; Belongs to the serpin family.	0.643