HSP90AA1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHSA1	ENSPPYP00000005659	ENSPPYP00000006854	ENSPPYP00000005659	AHSA1 isoform 1.	annotation not available	0.697
AHSA1	ENSPPYP00000015333	ENSPPYP00000006854	ENSPPYP00000015333	AHSA1 isoform 1.	annotation not available	0.896
AHSA1	ENSPPYP00000016659	ENSPPYP00000006854	ENSPPYP00000016659	AHSA1 isoform 1.	annotation not available	0.896
AHSA1	FKBP4	ENSPPYP00000006854	ENSPPYP00000004732	AHSA1 isoform 1.	Peptidylprolyl isomerase.	0.892
AHSA1	HSP90AA1	ENSPPYP00000006854	ENSPPYP00000006994	AHSA1 isoform 1.	HSP90AA1 isoform 6.	0.922
AHSA1	HSP90AB1	ENSPPYP00000006854	ENSPPYP00000018631	AHSA1 isoform 1.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.982
AHSA1	HSPA4	ENSPPYP00000006854	ENSPPYP00000017643	AHSA1 isoform 1.	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.638
AHSA1	HSPA8	ENSPPYP00000006854	ENSPPYP00000004564	AHSA1 isoform 1.	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.697
AHSA1	PTGES3	ENSPPYP00000006854	ENSPPYP00000005319	AHSA1 isoform 1.	Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.	0.865
AHSA1	STIP1	ENSPPYP00000006854	ENSPPYP00000003602	AHSA1 isoform 1.	STIP1 isoform 2.	0.973
ENSPPYP00000005659	AHSA1	ENSPPYP00000005659	ENSPPYP00000006854	annotation not available	AHSA1 isoform 1.	0.697
ENSPPYP00000005659	ENSPPYP00000015333	ENSPPYP00000005659	ENSPPYP00000015333	annotation not available	annotation not available	0.934
ENSPPYP00000005659	ENSPPYP00000016659	ENSPPYP00000005659	ENSPPYP00000016659	annotation not available	annotation not available	0.934
ENSPPYP00000005659	FKBP4	ENSPPYP00000005659	ENSPPYP00000004732	annotation not available	Peptidylprolyl isomerase.	0.522
ENSPPYP00000005659	HSP90AA1	ENSPPYP00000005659	ENSPPYP00000006994	annotation not available	HSP90AA1 isoform 6.	0.958
ENSPPYP00000005659	HSP90AB1	ENSPPYP00000005659	ENSPPYP00000018631	annotation not available	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.985
ENSPPYP00000005659	HSPA4	ENSPPYP00000005659	ENSPPYP00000017643	annotation not available	Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family.	0.942
ENSPPYP00000005659	PTGES3	ENSPPYP00000005659	ENSPPYP00000005319	annotation not available	Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.	0.584
ENSPPYP00000005659	STIP1	ENSPPYP00000005659	ENSPPYP00000003602	annotation not available	STIP1 isoform 2.	0.912
ENSPPYP00000015333	AHSA1	ENSPPYP00000015333	ENSPPYP00000006854	annotation not available	AHSA1 isoform 1.	0.896