| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACTB | ACTG1 | ENSPPYP00000019427 | ENSPPYP00000009805 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | ACTG1 isoform 10. | 0.999 |
| ACTB | AHNAK2 | ENSPPYP00000019427 | ENSPPYP00000007040 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | AHNAK2 isoform 1. | 0.914 |
| ACTB | ANXA2 | ENSPPYP00000019427 | ENSPPYP00000007399 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family. | 0.858 |
| ACTB | FLNB | ENSPPYP00000019427 | ENSPPYP00000015399 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | FLNB isoform 3. | 0.429 |
| ACTB | HNRNPA2B1 | ENSPPYP00000019427 | ENSPPYP00000019858 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Heterogeneous nuclear ribonucleoproteins A2/B1; Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and he [...] | 0.461 |
| ACTB | MSL3 | ENSPPYP00000019427 | ENSPPYP00000022509 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Male-specific lethal 3 homolog; May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (By similarity). | 0.450 |
| ACTG1 | ACTB | ENSPPYP00000009805 | ENSPPYP00000019427 | ACTG1 isoform 10. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.999 |
| ACTG1 | AHNAK2 | ENSPPYP00000009805 | ENSPPYP00000007040 | ACTG1 isoform 10. | AHNAK2 isoform 1. | 0.914 |
| ACTG1 | ANXA2 | ENSPPYP00000009805 | ENSPPYP00000007399 | ACTG1 isoform 10. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family. | 0.637 |
| ACTG1 | FLNB | ENSPPYP00000009805 | ENSPPYP00000015399 | ACTG1 isoform 10. | FLNB isoform 3. | 0.429 |
| AHNAK2 | ACTB | ENSPPYP00000007040 | ENSPPYP00000019427 | AHNAK2 isoform 1. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.914 |
| AHNAK2 | ACTG1 | ENSPPYP00000007040 | ENSPPYP00000009805 | AHNAK2 isoform 1. | ACTG1 isoform 10. | 0.914 |
| AHNAK2 | ANXA2 | ENSPPYP00000007040 | ENSPPYP00000007399 | AHNAK2 isoform 1. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family. | 0.956 |
| AHNAK2 | ENSPPYP00000007041 | ENSPPYP00000007040 | ENSPPYP00000007041 | AHNAK2 isoform 1. | annotation not available | 0.738 |
| AHNAK2 | ENSPPYP00000007042 | ENSPPYP00000007040 | ENSPPYP00000007042 | AHNAK2 isoform 1. | annotation not available | 0.724 |
| AHNAK2 | FLNB | ENSPPYP00000007040 | ENSPPYP00000015399 | AHNAK2 isoform 1. | FLNB isoform 3. | 0.489 |
| AHNAK2 | HNRNPA2B1 | ENSPPYP00000007040 | ENSPPYP00000019858 | AHNAK2 isoform 1. | Heterogeneous nuclear ribonucleoproteins A2/B1; Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and he [...] | 0.524 |
| AHNAK2 | MSL2 | ENSPPYP00000007040 | ENSPPYP00000015805 | AHNAK2 isoform 1. | MSL2 isoform 4. | 0.513 |
| AHNAK2 | MSL3 | ENSPPYP00000007040 | ENSPPYP00000022509 | AHNAK2 isoform 1. | Male-specific lethal 3 homolog; May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (By similarity). | 0.517 |
| AHNAK2 | S100A10 | ENSPPYP00000007040 | ENSPPYP00000000992 | AHNAK2 isoform 1. | S100A10 isoform 1; Belongs to the S-100 family. | 0.957 |
