UBE3A protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	ESR1	ENSPPYP00000015644	ENSPPYP00000019159	CTNNB1 isoform 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.569
CTNNB1	PSMD14	ENSPPYP00000015644	ENSPPYP00000014374	CTNNB1 isoform 2.	Proteasome 26S subunit, non-ATPase 14.	0.505
CTNNB1	SCRIB	ENSPPYP00000015644	ENSPPYP00000021255	CTNNB1 isoform 2.	SCRIB isoform 2.	0.475
CTNNB1	TP53	ENSPPYP00000015644	ENSPPYP00000008923	CTNNB1 isoform 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.697
CTNNB1	UBE3A	ENSPPYP00000015644	ENSPPYP00000007109	CTNNB1 isoform 2.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.977
DLG1	SCRIB	ENSPPYP00000016163	ENSPPYP00000021255	DLG1 isoform 5; Belongs to the MAGUK family.	SCRIB isoform 2.	0.897
DLG1	UBE3A	ENSPPYP00000016163	ENSPPYP00000007109	DLG1 isoform 5; Belongs to the MAGUK family.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.925
ESR1	CTNNB1	ENSPPYP00000019159	ENSPPYP00000015644	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	CTNNB1 isoform 2.	0.569
ESR1	TP53	ENSPPYP00000019159	ENSPPYP00000008923	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.942
ESR1	TSC2	ENSPPYP00000019159	ENSPPYP00000007907	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	TSC2 isoform 1.	0.649
ESR1	UBE3A	ENSPPYP00000019159	ENSPPYP00000007109	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.923
NFX1	RAD23A	ENSPPYP00000021440	ENSPPYP00000010781	NFX1 isoform 1.	RAD23A isoform 1.	0.449
NFX1	UBE3A	ENSPPYP00000021440	ENSPPYP00000007109	NFX1 isoform 1.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.922
PSMD14	CTNNB1	ENSPPYP00000014374	ENSPPYP00000015644	Proteasome 26S subunit, non-ATPase 14.	CTNNB1 isoform 2.	0.505
PSMD14	PSMD4	ENSPPYP00000014374	ENSPPYP00000024378	Proteasome 26S subunit, non-ATPase 14.	PSMD4 isoform 1.	0.999
PSMD14	RAD23A	ENSPPYP00000014374	ENSPPYP00000010781	Proteasome 26S subunit, non-ATPase 14.	RAD23A isoform 1.	0.845
PSMD14	TP53	ENSPPYP00000014374	ENSPPYP00000008923	Proteasome 26S subunit, non-ATPase 14.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.557
PSMD14	UBE3A	ENSPPYP00000014374	ENSPPYP00000007109	Proteasome 26S subunit, non-ATPase 14.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.924
PSMD4	PSMD14	ENSPPYP00000024378	ENSPPYP00000014374	PSMD4 isoform 1.	Proteasome 26S subunit, non-ATPase 14.	0.999
PSMD4	RAD23A	ENSPPYP00000024378	ENSPPYP00000010781	PSMD4 isoform 1.	RAD23A isoform 1.	0.958