| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCZ1 | RAB7A | ENSPPYP00000019450 | ENSPPYP00000015022 | CCZ1B isoform 5. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.988 |
| CCZ1 | STX17 | ENSPPYP00000019450 | ENSPPYP00000021787 | CCZ1B isoform 5. | STX17 isoform 1; Belongs to the syntaxin family. | 0.411 |
| CCZ1 | VPS11 | ENSPPYP00000019450 | ENSPPYP00000004530 | CCZ1B isoform 5. | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.872 |
| CCZ1 | VPS16 | ENSPPYP00000019450 | ENSPPYP00000012098 | CCZ1B isoform 5. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. | 0.866 |
| CCZ1 | VPS18 | ENSPPYP00000019450 | ENSPPYP00000007209 | CCZ1B isoform 5. | VPS18 core subunit of CORVET and HOPS complexes. | 0.870 |
| CCZ1 | VPS33A | ENSPPYP00000019450 | ENSPPYP00000005771 | CCZ1B isoform 5. | T0002578 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. | 0.754 |
| CCZ1 | VPS33B | ENSPPYP00000019450 | ENSPPYP00000007705 | CCZ1B isoform 5. | VPS33B isoform 1; Belongs to the STXBP/unc-18/SEC1 family. | 0.744 |
| CCZ1 | VPS39 | ENSPPYP00000019450 | ENSPPYP00000007240 | CCZ1B isoform 5. | VPS39 isoform 1. | 0.870 |
| CCZ1 | VPS41 | ENSPPYP00000019450 | ENSPPYP00000019750 | CCZ1B isoform 5. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. | 0.836 |
| RAB7A | CCZ1 | ENSPPYP00000015022 | ENSPPYP00000019450 | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | CCZ1B isoform 5. | 0.988 |
| RAB7A | VPS11 | ENSPPYP00000015022 | ENSPPYP00000004530 | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.979 |
| RAB7A | VPS16 | ENSPPYP00000015022 | ENSPPYP00000012098 | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. | 0.937 |
| RAB7A | VPS18 | ENSPPYP00000015022 | ENSPPYP00000007209 | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | VPS18 core subunit of CORVET and HOPS complexes. | 0.959 |
| RAB7A | VPS33A | ENSPPYP00000015022 | ENSPPYP00000005771 | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | T0002578 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. | 0.939 |
| RAB7A | VPS39 | ENSPPYP00000015022 | ENSPPYP00000007240 | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | VPS39 isoform 1. | 0.959 |
| RAB7A | VPS41 | ENSPPYP00000015022 | ENSPPYP00000019750 | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. | 0.959 |
| RB1 | VPS39 | ENSPPYP00000006102 | ENSPPYP00000007240 | RB1 isoform 1. | VPS39 isoform 1. | 0.888 |
| STX17 | CCZ1 | ENSPPYP00000021787 | ENSPPYP00000019450 | STX17 isoform 1; Belongs to the syntaxin family. | CCZ1B isoform 5. | 0.411 |
| STX17 | VPS11 | ENSPPYP00000021787 | ENSPPYP00000004530 | STX17 isoform 1; Belongs to the syntaxin family. | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.843 |
| STX17 | VPS16 | ENSPPYP00000021787 | ENSPPYP00000012098 | STX17 isoform 1; Belongs to the syntaxin family. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. | 0.774 |
