SNAP23 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SNAP23	STX12	ENSPPYP00000007248	ENSPPYP00000001911	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	0.985
SNAP23	STX1A	ENSPPYP00000007248	ENSPPYP00000019613	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...]	0.997
SNAP23	STX1B	ENSPPYP00000007248	ENSPPYP00000008248	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	STX1B isoform 1; Belongs to the syntaxin family.	0.987
SNAP23	STX2	ENSPPYP00000007248	ENSPPYP00000005839	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	STX2 isoform 2; Belongs to the syntaxin family.	0.996
SNAP23	STX3	ENSPPYP00000007248	ENSPPYP00000003718	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	STX3 isoform 3; Belongs to the syntaxin family.	0.997
SNAP23	STX4	ENSPPYP00000007248	ENSPPYP00000008249	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	STX4 isoform 4; Belongs to the syntaxin family.	0.999
SNAP23	VAMP1	ENSPPYP00000007248	ENSPPYP00000004772	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle associated membrane protein 1.	0.991
SNAP23	VAMP2	ENSPPYP00000007248	ENSPPYP00000008938	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	VAMP2 isoform 2.	0.997
SNAP23	VAMP3	ENSPPYP00000007248	ENSPPYP00000002240	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle associated membrane protein 3.	0.999
SNAP23	VAMP7	ENSPPYP00000007248	ENSPPYP00000023405	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...]	0.993
STX12	SNAP23	ENSPPYP00000001911	ENSPPYP00000007248	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.985
STX12	STX1A	ENSPPYP00000001911	ENSPPYP00000019613	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...]	0.944
STX12	STX1B	ENSPPYP00000001911	ENSPPYP00000008248	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	STX1B isoform 1; Belongs to the syntaxin family.	0.748
STX12	STX2	ENSPPYP00000001911	ENSPPYP00000005839	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	STX2 isoform 2; Belongs to the syntaxin family.	0.754
STX12	STX3	ENSPPYP00000001911	ENSPPYP00000003718	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	STX3 isoform 3; Belongs to the syntaxin family.	0.748
STX12	STX4	ENSPPYP00000001911	ENSPPYP00000008249	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	STX4 isoform 4; Belongs to the syntaxin family.	0.927
STX12	VAMP1	ENSPPYP00000001911	ENSPPYP00000004772	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	Vesicle associated membrane protein 1.	0.573
STX12	VAMP2	ENSPPYP00000001911	ENSPPYP00000008938	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	VAMP2 isoform 2.	0.695
STX12	VAMP3	ENSPPYP00000001911	ENSPPYP00000002240	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	Vesicle associated membrane protein 3.	0.869
STX12	VAMP7	ENSPPYP00000001911	ENSPPYP00000023405	Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).	Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...]	0.990