| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1B1 | AKR1B10 | ENSPPYP00000020215 | ENSPPYP00000020216 | Aldo-keto reductase family 1 member B. | Aldo-keto reductase family 1 member B10. | 0.945 |
| AKR1B1 | DCXR | ENSPPYP00000020215 | ENSPPYP00000009838 | Aldo-keto reductase family 1 member B. | DCXR isoform 2. | 0.915 |
| AKR1B1 | HK1 | ENSPPYP00000020215 | ENSPPYP00000002765 | Aldo-keto reductase family 1 member B. | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | 0.833 |
| AKR1B1 | HK2 | ENSPPYP00000020215 | ENSPPYP00000013670 | Aldo-keto reductase family 1 member B. | HK2 isoform 1. | 0.847 |
| AKR1B1 | HK3 | ENSPPYP00000020215 | ENSPPYP00000017995 | Aldo-keto reductase family 1 member B. | HK3 isoform 2. | 0.848 |
| AKR1B1 | HKDC1 | ENSPPYP00000020215 | ENSPPYP00000002767 | Aldo-keto reductase family 1 member B. | Hexokinase domain containing 1. | 0.835 |
| AKR1B1 | SORD | ENSPPYP00000020215 | ENSPPYP00000007292 | Aldo-keto reductase family 1 member B. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.967 |
| AKR1B10 | AKR1B1 | ENSPPYP00000020216 | ENSPPYP00000020215 | Aldo-keto reductase family 1 member B10. | Aldo-keto reductase family 1 member B. | 0.945 |
| AKR1B10 | DCXR | ENSPPYP00000020216 | ENSPPYP00000009838 | Aldo-keto reductase family 1 member B10. | DCXR isoform 2. | 0.907 |
| AKR1B10 | HK1 | ENSPPYP00000020216 | ENSPPYP00000002765 | Aldo-keto reductase family 1 member B10. | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | 0.817 |
| AKR1B10 | HK2 | ENSPPYP00000020216 | ENSPPYP00000013670 | Aldo-keto reductase family 1 member B10. | HK2 isoform 1. | 0.822 |
| AKR1B10 | HK3 | ENSPPYP00000020216 | ENSPPYP00000017995 | Aldo-keto reductase family 1 member B10. | HK3 isoform 2. | 0.822 |
| AKR1B10 | HKDC1 | ENSPPYP00000020216 | ENSPPYP00000002767 | Aldo-keto reductase family 1 member B10. | Hexokinase domain containing 1. | 0.917 |
| AKR1B10 | SORD | ENSPPYP00000020216 | ENSPPYP00000007292 | Aldo-keto reductase family 1 member B10. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.935 |
| DCXR | AKR1B1 | ENSPPYP00000009838 | ENSPPYP00000020215 | DCXR isoform 2. | Aldo-keto reductase family 1 member B. | 0.915 |
| DCXR | AKR1B10 | ENSPPYP00000009838 | ENSPPYP00000020216 | DCXR isoform 2. | Aldo-keto reductase family 1 member B10. | 0.907 |
| DCXR | SORD | ENSPPYP00000009838 | ENSPPYP00000007292 | DCXR isoform 2. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.917 |
| FCSK | HK1 | ENSPPYP00000024132 | ENSPPYP00000002765 | FUK isoform 2. | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | 0.831 |
| FCSK | HK2 | ENSPPYP00000024132 | ENSPPYP00000013670 | FUK isoform 2. | HK2 isoform 1. | 0.831 |
| FCSK | HK3 | ENSPPYP00000024132 | ENSPPYP00000017995 | FUK isoform 2. | HK3 isoform 2. | 0.831 |
