node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADHFE1 | SORD | ENSPPYP00000020906 | ENSPPYP00000007292 | Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.903 |
ADHFE1 | XYLB | ENSPPYP00000020906 | ENSPPYP00000015667 | Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). | Xylulose kinase; Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. | 0.495 |
AKR1B1 | AKR1B10 | ENSPPYP00000020215 | ENSPPYP00000020216 | Aldo-keto reductase family 1 member B. | Aldo-keto reductase family 1 member B10. | 0.920 |
AKR1B1 | HK1 | ENSPPYP00000020215 | ENSPPYP00000002765 | Aldo-keto reductase family 1 member B. | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | 0.826 |
AKR1B1 | HK2 | ENSPPYP00000020215 | ENSPPYP00000013670 | Aldo-keto reductase family 1 member B. | HK2 isoform 1. | 0.833 |
AKR1B1 | HK3 | ENSPPYP00000020215 | ENSPPYP00000017995 | Aldo-keto reductase family 1 member B. | HK3 isoform 2. | 0.834 |
AKR1B1 | HKDC1 | ENSPPYP00000020215 | ENSPPYP00000002767 | Aldo-keto reductase family 1 member B. | Hexokinase domain containing 1. | 0.826 |
AKR1B1 | KHK | ENSPPYP00000020215 | ENSPPYP00000014032 | Aldo-keto reductase family 1 member B. | Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. | 0.450 |
AKR1B1 | SORD | ENSPPYP00000020215 | ENSPPYP00000007292 | Aldo-keto reductase family 1 member B. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.943 |
AKR1B1 | XYLB | ENSPPYP00000020215 | ENSPPYP00000015667 | Aldo-keto reductase family 1 member B. | Xylulose kinase; Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. | 0.479 |
AKR1B10 | AKR1B1 | ENSPPYP00000020216 | ENSPPYP00000020215 | Aldo-keto reductase family 1 member B10. | Aldo-keto reductase family 1 member B. | 0.920 |
AKR1B10 | HK1 | ENSPPYP00000020216 | ENSPPYP00000002765 | Aldo-keto reductase family 1 member B10. | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | 0.816 |
AKR1B10 | HK2 | ENSPPYP00000020216 | ENSPPYP00000013670 | Aldo-keto reductase family 1 member B10. | HK2 isoform 1. | 0.817 |
AKR1B10 | HK3 | ENSPPYP00000020216 | ENSPPYP00000017995 | Aldo-keto reductase family 1 member B10. | HK3 isoform 2. | 0.817 |
AKR1B10 | HKDC1 | ENSPPYP00000020216 | ENSPPYP00000002767 | Aldo-keto reductase family 1 member B10. | Hexokinase domain containing 1. | 0.943 |
AKR1B10 | SORD | ENSPPYP00000020216 | ENSPPYP00000007292 | Aldo-keto reductase family 1 member B10. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.927 |
COQ2 | SORD | ENSPPYP00000023711 | ENSPPYP00000007292 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2- oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). | 0.897 |
HK1 | AKR1B1 | ENSPPYP00000002765 | ENSPPYP00000020215 | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | Aldo-keto reductase family 1 member B. | 0.826 |
HK1 | AKR1B10 | ENSPPYP00000002765 | ENSPPYP00000020216 | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | Aldo-keto reductase family 1 member B10. | 0.816 |
HK1 | HK2 | ENSPPYP00000002765 | ENSPPYP00000013670 | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | HK2 isoform 1. | 0.974 |