DUOXA2 protein (Pongo abelii) - STRING interaction network

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	DUOX1	ENSPPYP00000020105	ENSPPYP00000007298	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	DUOX1 isoform 1.	0.436
CAV1	DUOX2	ENSPPYP00000020105	ENSPPYP00000007295	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	DUOX2 isoform 1.	0.401
CAV1	DUOXA1	ENSPPYP00000020105	ENSPPYP00000007297	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	Dual oxidase maturation factor 1.	0.773
CAV1	DUOXA2	ENSPPYP00000020105	ENSPPYP00000007296	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	Dual oxidase maturation factor 2.	0.811
CAV1	NOX4	ENSPPYP00000020105	ENSPPYP00000004298	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity).	0.507
CAV1	TXNDC11	ENSPPYP00000020105	ENSPPYP00000008039	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	Thioredoxin domain containing 11.	0.811
DUOX1	CAV1	ENSPPYP00000007298	ENSPPYP00000020105	DUOX1 isoform 1.	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	0.436
DUOX1	DUOX2	ENSPPYP00000007298	ENSPPYP00000007295	DUOX1 isoform 1.	DUOX2 isoform 1.	0.990
DUOX1	DUOXA1	ENSPPYP00000007298	ENSPPYP00000007297	DUOX1 isoform 1.	Dual oxidase maturation factor 1.	0.987
DUOX1	DUOXA2	ENSPPYP00000007298	ENSPPYP00000007296	DUOX1 isoform 1.	Dual oxidase maturation factor 2.	0.994
DUOX1	NOX3	ENSPPYP00000007298	ENSPPYP00000019175	DUOX1 isoform 1.	NOX3 isoform 1.	0.682
DUOX1	NOX4	ENSPPYP00000007298	ENSPPYP00000004298	DUOX1 isoform 1.	NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity).	0.671
DUOX1	NOX5	ENSPPYP00000007298	ENSPPYP00000007478	DUOX1 isoform 1.	NOX5 isoform 4.	0.673
DUOX1	TXNDC11	ENSPPYP00000007298	ENSPPYP00000008039	DUOX1 isoform 1.	Thioredoxin domain containing 11.	0.533
DUOX2	CAV1	ENSPPYP00000007295	ENSPPYP00000020105	DUOX2 isoform 1.	Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...]	0.401
DUOX2	DUOX1	ENSPPYP00000007295	ENSPPYP00000007298	DUOX2 isoform 1.	DUOX1 isoform 1.	0.990
DUOX2	DUOXA1	ENSPPYP00000007295	ENSPPYP00000007297	DUOX2 isoform 1.	Dual oxidase maturation factor 1.	0.953
DUOX2	DUOXA2	ENSPPYP00000007295	ENSPPYP00000007296	DUOX2 isoform 1.	Dual oxidase maturation factor 2.	0.999
DUOX2	IYD	ENSPPYP00000007295	ENSPPYP00000019149	DUOX2 isoform 1.	Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.	0.820
DUOX2	NOX3	ENSPPYP00000007295	ENSPPYP00000019175	DUOX2 isoform 1.	NOX3 isoform 1.	0.602