| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AK9 | CMPK1 | ENSPPYP00000018934 | ENSPPYP00000001599 | AK9 isoform 2. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.939 |
| AK9 | DTYMK | ENSPPYP00000018934 | ENSPPYP00000014942 | AK9 isoform 2. | DTYMK isoform 1. | 0.949 |
| AK9 | DUT | ENSPPYP00000018934 | ENSPPYP00000007314 | AK9 isoform 2. | Deoxyuridine triphosphatase. | 0.942 |
| AK9 | ITPA | ENSPPYP00000018934 | ENSPPYP00000012088 | AK9 isoform 2. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.930 |
| AK9 | NME2 | ENSPPYP00000018934 | ENSPPYP00000005726 | AK9 isoform 2. | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] | 0.944 |
| AK9 | NME6 | ENSPPYP00000018934 | ENSPPYP00000015557 | AK9 isoform 2. | Nucleoside diphosphate kinase. | 0.944 |
| CMPK1 | AK9 | ENSPPYP00000001599 | ENSPPYP00000018934 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | AK9 isoform 2. | 0.939 |
| CMPK1 | DCTD | ENSPPYP00000001599 | ENSPPYP00000017005 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.927 |
| CMPK1 | DTYMK | ENSPPYP00000001599 | ENSPPYP00000014942 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | DTYMK isoform 1. | 0.754 |
| CMPK1 | DUT | ENSPPYP00000001599 | ENSPPYP00000007314 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Deoxyuridine triphosphatase. | 0.931 |
| CMPK1 | NME2 | ENSPPYP00000001599 | ENSPPYP00000005726 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] | 0.950 |
| CMPK1 | NME6 | ENSPPYP00000001599 | ENSPPYP00000015557 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Nucleoside diphosphate kinase. | 0.935 |
| CMPK1 | TK1 | ENSPPYP00000001599 | ENSPPYP00000009752 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Thymidine kinase. | 0.910 |
| CMPK1 | TK2 | ENSPPYP00000001599 | ENSPPYP00000008383 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Thymidine kinase 2, mitochondrial isoform X2. | 0.935 |
| DCTD | CMPK1 | ENSPPYP00000017005 | ENSPPYP00000001599 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.927 |
| DCTD | DTYMK | ENSPPYP00000017005 | ENSPPYP00000014942 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | DTYMK isoform 1. | 0.969 |
| DCTD | DUT | ENSPPYP00000017005 | ENSPPYP00000007314 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Deoxyuridine triphosphatase. | 0.949 |
| DCTD | TK1 | ENSPPYP00000017005 | ENSPPYP00000009752 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidine kinase. | 0.971 |
| DCTD | TK2 | ENSPPYP00000017005 | ENSPPYP00000008383 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidine kinase 2, mitochondrial isoform X2. | 0.963 |
| DCTD | TYMS | ENSPPYP00000017005 | ENSPPYP00000010155 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidylate synthetase. | 0.986 |
