| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CENPJ | CEP135 | ENSPPYP00000005941 | ENSPPYP00000016481 | CENPJ isoform 2. | CEP135 isoform 2. | 0.953 |
| CENPJ | CEP152 | ENSPPYP00000005941 | ENSPPYP00000007316 | CENPJ isoform 2. | CEP152 isoform 2. | 0.967 |
| CENPJ | CEP192 | ENSPPYP00000005941 | ENSPPYP00000024129 | CENPJ isoform 2. | CEP192 isoform 7. | 0.741 |
| CENPJ | CEP295 | ENSPPYP00000005941 | ENSPPYP00000004317 | CENPJ isoform 2. | CEP295 isoform 1. | 0.555 |
| CENPJ | CEP63 | ENSPPYP00000005941 | ENSPPYP00000015800 | CENPJ isoform 2. | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | 0.706 |
| CENPJ | PCNT | ENSPPYP00000005941 | ENSPPYP00000012874 | CENPJ isoform 2. | PCNT isoform 1. | 0.794 |
| CENPJ | PLK1 | ENSPPYP00000005941 | ENSPPYP00000008136 | CENPJ isoform 2. | Serine/threonine-protein kinase PLK. | 0.791 |
| CENPJ | PLK4 | ENSPPYP00000005941 | ENSPPYP00000016820 | CENPJ isoform 2. | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...] | 0.945 |
| CENPJ | SASS6 | ENSPPYP00000005941 | ENSPPYP00000001299 | CENPJ isoform 2. | SAS-6 centriolar assembly protein. | 0.956 |
| CENPJ | STIL | ENSPPYP00000005941 | ENSPPYP00000001600 | CENPJ isoform 2. | STIL isoform 3. | 0.966 |
| CEP135 | CENPJ | ENSPPYP00000016481 | ENSPPYP00000005941 | CEP135 isoform 2. | CENPJ isoform 2. | 0.953 |
| CEP135 | CEP152 | ENSPPYP00000016481 | ENSPPYP00000007316 | CEP135 isoform 2. | CEP152 isoform 2. | 0.840 |
| CEP135 | CEP192 | ENSPPYP00000016481 | ENSPPYP00000024129 | CEP135 isoform 2. | CEP192 isoform 7. | 0.708 |
| CEP135 | CEP295 | ENSPPYP00000016481 | ENSPPYP00000004317 | CEP135 isoform 2. | CEP295 isoform 1. | 0.749 |
| CEP135 | CEP63 | ENSPPYP00000016481 | ENSPPYP00000015800 | CEP135 isoform 2. | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | 0.653 |
| CEP135 | PCNT | ENSPPYP00000016481 | ENSPPYP00000012874 | CEP135 isoform 2. | PCNT isoform 1. | 0.706 |
| CEP135 | PLK1 | ENSPPYP00000016481 | ENSPPYP00000008136 | CEP135 isoform 2. | Serine/threonine-protein kinase PLK. | 0.949 |
| CEP135 | PLK4 | ENSPPYP00000016481 | ENSPPYP00000016820 | CEP135 isoform 2. | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...] | 0.867 |
| CEP135 | SASS6 | ENSPPYP00000016481 | ENSPPYP00000001299 | CEP135 isoform 2. | SAS-6 centriolar assembly protein. | 0.827 |
| CEP135 | STIL | ENSPPYP00000016481 | ENSPPYP00000001600 | CEP135 isoform 2. | STIL isoform 3. | 0.626 |
