GNB5 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0054588	GNAO1	ENSPPYP00000007817	ENSPPYP00000008317	RGS11 isoform 4.	GNAO1 isoform 1.	0.620
CR201_G0054588	GNB5	ENSPPYP00000007817	ENSPPYP00000007348	RGS11 isoform 4.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.982
CR201_G0054588	PDCL	ENSPPYP00000007817	ENSPPYP00000021943	RGS11 isoform 4.	PDCL isoform 2.	0.609
CR201_G0054588	RGS6	ENSPPYP00000007817	ENSPPYP00000006776	RGS11 isoform 4.	Regulator of G protein signaling 6.	0.576
CR201_G0054588	RGS7	ENSPPYP00000007817	ENSPPYP00000000070	RGS11 isoform 4.	RGS7 isoform 3.	0.576
GABBR2	GNAO1	ENSPPYP00000021779	ENSPPYP00000008317	GABBR2 isoform 2.	GNAO1 isoform 1.	0.937
GABBR2	GNB5	ENSPPYP00000021779	ENSPPYP00000007348	GABBR2 isoform 2.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.965
GABBR2	GNG12	ENSPPYP00000021779	ENSPPYP00000001459	GABBR2 isoform 2.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.955
GABBR2	GNG3	ENSPPYP00000021779	ENSPPYP00000003639	GABBR2 isoform 2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.954
GNAO1	CR201_G0054588	ENSPPYP00000008317	ENSPPYP00000007817	GNAO1 isoform 1.	RGS11 isoform 4.	0.620
GNAO1	GABBR2	ENSPPYP00000008317	ENSPPYP00000021779	GNAO1 isoform 1.	GABBR2 isoform 2.	0.937
GNAO1	GNAS	ENSPPYP00000008317	ENSPPYP00000012485	GNAO1 isoform 1.	GNAS isoform 2.	0.739
GNAO1	GNB5	ENSPPYP00000008317	ENSPPYP00000007348	GNAO1 isoform 1.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.978
GNAO1	GNG12	ENSPPYP00000008317	ENSPPYP00000001459	GNAO1 isoform 1.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.961
GNAO1	GNG3	ENSPPYP00000008317	ENSPPYP00000003639	GNAO1 isoform 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.987
GNAO1	RGS6	ENSPPYP00000008317	ENSPPYP00000006776	GNAO1 isoform 1.	Regulator of G protein signaling 6.	0.692
GNAO1	RGS7	ENSPPYP00000008317	ENSPPYP00000000070	GNAO1 isoform 1.	RGS7 isoform 3.	0.753
GNAO1	RGS9	ENSPPYP00000008317	ENSPPYP00000009608	GNAO1 isoform 1.	RGS9 isoform 9.	0.620
GNAS	GNAO1	ENSPPYP00000012485	ENSPPYP00000008317	GNAS isoform 2.	GNAO1 isoform 1.	0.739
GNAS	GNB5	ENSPPYP00000012485	ENSPPYP00000007348	GNAS isoform 2.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.968