| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IGF1R | NEDD4 | ENSPPYP00000007720 | ENSPPYP00000007372 | Tyrosine-protein kinase receptor. | E3 ubiquitin-protein ligase. | 0.933 |
| IGF1R | NEDD4L | ENSPPYP00000007720 | ENSPPYP00000010317 | Tyrosine-protein kinase receptor. | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...] | 0.772 |
| IGF1R | PTEN | ENSPPYP00000007720 | ENSPPYP00000002838 | Tyrosine-protein kinase receptor. | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.647 |
| ISG15 | NEDD4 | ENSPPYP00000002343 | ENSPPYP00000007372 | ISG15 ubiquitin like modifier. | E3 ubiquitin-protein ligase. | 0.973 |
| ISG15 | NEDD4L | ENSPPYP00000002343 | ENSPPYP00000010317 | ISG15 ubiquitin like modifier. | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...] | 0.858 |
| ISG15 | TSG101 | ENSPPYP00000002343 | ENSPPYP00000003942 | ISG15 ubiquitin like modifier. | TSG101 isoform 4. | 0.623 |
| ISG15 | UBC | ENSPPYP00000002343 | ENSPPYP00000005811 | ISG15 ubiquitin like modifier. | UBC isoform 2. | 0.404 |
| NDFIP1 | NEDD4 | ENSPPYP00000017780 | ENSPPYP00000007372 | Nedd4 family interacting protein 1. | E3 ubiquitin-protein ligase. | 0.933 |
| NDFIP1 | NEDD4L | ENSPPYP00000017780 | ENSPPYP00000010317 | Nedd4 family interacting protein 1. | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...] | 0.835 |
| NDFIP1 | PTEN | ENSPPYP00000017780 | ENSPPYP00000002838 | Nedd4 family interacting protein 1. | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.776 |
| NDFIP2 | NEDD4 | ENSPPYP00000006190 | ENSPPYP00000007372 | NDFIP2 isoform 1. | E3 ubiquitin-protein ligase. | 0.965 |
| NDFIP2 | NEDD4L | ENSPPYP00000006190 | ENSPPYP00000010317 | NDFIP2 isoform 1. | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...] | 0.850 |
| NEDD4 | IGF1R | ENSPPYP00000007372 | ENSPPYP00000007720 | E3 ubiquitin-protein ligase. | Tyrosine-protein kinase receptor. | 0.933 |
| NEDD4 | ISG15 | ENSPPYP00000007372 | ENSPPYP00000002343 | E3 ubiquitin-protein ligase. | ISG15 ubiquitin like modifier. | 0.973 |
| NEDD4 | NDFIP1 | ENSPPYP00000007372 | ENSPPYP00000017780 | E3 ubiquitin-protein ligase. | Nedd4 family interacting protein 1. | 0.933 |
| NEDD4 | NDFIP2 | ENSPPYP00000007372 | ENSPPYP00000006190 | E3 ubiquitin-protein ligase. | NDFIP2 isoform 1. | 0.965 |
| NEDD4 | NEDD4L | ENSPPYP00000007372 | ENSPPYP00000010317 | E3 ubiquitin-protein ligase. | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...] | 0.960 |
| NEDD4 | PTEN | ENSPPYP00000007372 | ENSPPYP00000002838 | E3 ubiquitin-protein ligase. | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.964 |
| NEDD4 | SCNN1A | ENSPPYP00000007372 | ENSPPYP00000004767 | E3 ubiquitin-protein ligase. | SCNN1A isoform 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. | 0.962 |
| NEDD4 | TSG101 | ENSPPYP00000007372 | ENSPPYP00000003942 | E3 ubiquitin-protein ligase. | TSG101 isoform 4. | 0.944 |
