ENSPPYP00000007387 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	ENSPPYP00000007387	ENSPPYP00000015070	ENSPPYP00000007387	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	annotation not available	0.949
ADCY5	GNAI1	ENSPPYP00000015070	ENSPPYP00000020020	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(i) subunit alpha-1.	0.721
ADCY5	GNAI3	ENSPPYP00000015070	ENSPPYP00000001241	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.959
ADCY5	GNAO1	ENSPPYP00000015070	ENSPPYP00000008317	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAO1 isoform 1.	0.954
ADCY5	GNAS	ENSPPYP00000015070	ENSPPYP00000012485	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS isoform 2.	0.986
ADCY5	GNB1	ENSPPYP00000015070	ENSPPYP00000002307	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.983
ADCY5	GNB2	ENSPPYP00000015070	ENSPPYP00000019528	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNB2 isoform 1.	0.954
ADCY5	GNB3	ENSPPYP00000015070	ENSPPYP00000004790	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 3.	0.946
ENSPPYP00000007387	ADCY5	ENSPPYP00000007387	ENSPPYP00000015070	annotation not available	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.949
ENSPPYP00000007387	GABBR2	ENSPPYP00000007387	ENSPPYP00000021779	annotation not available	GABBR2 isoform 2.	0.952
ENSPPYP00000007387	GNAI1	ENSPPYP00000007387	ENSPPYP00000020020	annotation not available	Guanine nucleotide-binding protein G(i) subunit alpha-1.	0.950
ENSPPYP00000007387	GNAI3	ENSPPYP00000007387	ENSPPYP00000001241	annotation not available	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.982
ENSPPYP00000007387	GNAO1	ENSPPYP00000007387	ENSPPYP00000008317	annotation not available	GNAO1 isoform 1.	0.963
ENSPPYP00000007387	GNAS	ENSPPYP00000007387	ENSPPYP00000012485	annotation not available	GNAS isoform 2.	0.994
ENSPPYP00000007387	GNB1	ENSPPYP00000007387	ENSPPYP00000002307	annotation not available	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.976
ENSPPYP00000007387	GNB2	ENSPPYP00000007387	ENSPPYP00000019528	annotation not available	GNB2 isoform 1.	0.966
ENSPPYP00000007387	GNB3	ENSPPYP00000007387	ENSPPYP00000004790	annotation not available	G protein subunit beta 3.	0.975
ENSPPYP00000007387	OPRM1	ENSPPYP00000007387	ENSPPYP00000024191	annotation not available	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family.	0.963
GABBR2	ENSPPYP00000007387	ENSPPYP00000021779	ENSPPYP00000007387	GABBR2 isoform 2.	annotation not available	0.952
GABBR2	GNAI1	ENSPPYP00000021779	ENSPPYP00000020020	GABBR2 isoform 2.	Guanine nucleotide-binding protein G(i) subunit alpha-1.	0.420