| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CR201_G0000132 | SMAD2 | ENSPPYP00000006021 | ENSPPYP00000010275 | SMAD1 isoform 8. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.970 |
| CR201_G0000132 | SMAD3 | ENSPPYP00000006021 | ENSPPYP00000007465 | SMAD1 isoform 8. | Mothers against decapentaplegic homolog. | 0.991 |
| CR201_G0000132 | SMAD4 | ENSPPYP00000006021 | ENSPPYP00000010297 | SMAD1 isoform 8. | Mothers against decapentaplegic homolog. | 0.999 |
| CR201_G0000132 | SMAD5 | ENSPPYP00000006021 | ENSPPYP00000017676 | SMAD1 isoform 8. | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). | 0.994 |
| CR201_G0000132 | SMAD6 | ENSPPYP00000006021 | ENSPPYP00000007463 | SMAD1 isoform 8. | Mothers against decapentaplegic homolog. | 0.974 |
| CR201_G0000132 | SMAD7 | ENSPPYP00000006021 | ENSPPYP00000010278 | SMAD1 isoform 8. | Mothers against decapentaplegic homolog. | 0.966 |
| CR201_G0000132 | SMURF1 | ENSPPYP00000006021 | ENSPPYP00000019458 | SMAD1 isoform 8. | E3 ubiquitin-protein ligase. | 0.756 |
| CR201_G0000132 | SMURF2 | ENSPPYP00000006021 | ENSPPYP00000009604 | SMAD1 isoform 8. | E3 ubiquitin-protein ligase. | 0.914 |
| CR201_G0000132 | TGFBR1 | ENSPPYP00000006021 | ENSPPYP00000021783 | SMAD1 isoform 8. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.704 |
| RNF111 | SMAD2 | ENSPPYP00000007390 | ENSPPYP00000010275 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.828 |
| RNF111 | SMAD3 | ENSPPYP00000007390 | ENSPPYP00000007465 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] | Mothers against decapentaplegic homolog. | 0.880 |
| RNF111 | SMAD4 | ENSPPYP00000007390 | ENSPPYP00000010297 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] | Mothers against decapentaplegic homolog. | 0.400 |
| RNF111 | SMAD6 | ENSPPYP00000007390 | ENSPPYP00000007463 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] | Mothers against decapentaplegic homolog. | 0.919 |
| RNF111 | SMAD7 | ENSPPYP00000007390 | ENSPPYP00000010278 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] | Mothers against decapentaplegic homolog. | 0.991 |
| RNF111 | SMURF2 | ENSPPYP00000007390 | ENSPPYP00000009604 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] | E3 ubiquitin-protein ligase. | 0.457 |
| SMAD2 | CR201_G0000132 | ENSPPYP00000010275 | ENSPPYP00000006021 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | SMAD1 isoform 8. | 0.970 |
| SMAD2 | RNF111 | ENSPPYP00000010275 | ENSPPYP00000007390 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] | 0.828 |
| SMAD2 | SMAD3 | ENSPPYP00000010275 | ENSPPYP00000007465 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD2 | SMAD4 | ENSPPYP00000010275 | ENSPPYP00000010297 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD2 | SMAD5 | ENSPPYP00000010275 | ENSPPYP00000017676 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). | 0.858 |
