| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADPGK | ALDOA | ENSPPYP00000007509 | ENSPPYP00000024596 | ADPGK isoform 4. | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | 0.910 |
| ADPGK | ALDOB | ENSPPYP00000007509 | ENSPPYP00000021797 | ADPGK isoform 4. | Fructose-bisphosphate aldolase B. | 0.910 |
| ADPGK | ALDOC | ENSPPYP00000007509 | ENSPPYP00000009108 | ADPGK isoform 4. | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | 0.910 |
| ADPGK | GCK | ENSPPYP00000007509 | ENSPPYP00000019722 | ADPGK isoform 4. | Phosphotransferase. | 0.955 |
| ADPGK | GPI | ENSPPYP00000007509 | ENSPPYP00000011012 | ADPGK isoform 4. | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). | 0.984 |
| ADPGK | HK1 | ENSPPYP00000007509 | ENSPPYP00000002765 | ADPGK isoform 4. | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | 0.920 |
| ADPGK | HK2 | ENSPPYP00000007509 | ENSPPYP00000013670 | ADPGK isoform 4. | HK2 isoform 1. | 0.920 |
| ADPGK | HK3 | ENSPPYP00000007509 | ENSPPYP00000017995 | ADPGK isoform 4. | HK3 isoform 2. | 0.920 |
| ADPGK | HKDC1 | ENSPPYP00000007509 | ENSPPYP00000002767 | ADPGK isoform 4. | Hexokinase domain containing 1. | 0.920 |
| ADPGK | PGM2 | ENSPPYP00000007509 | ENSPPYP00000016381 | ADPGK isoform 4. | Phosphoglucomutase-2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5- phosphopentoses. May also catalyze the interconversion of glucose-1- phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity (By similarity). | 0.941 |
| ALDOA | ADPGK | ENSPPYP00000024596 | ENSPPYP00000007509 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | ADPGK isoform 4. | 0.910 |
| ALDOA | ALDOB | ENSPPYP00000024596 | ENSPPYP00000021797 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-bisphosphate aldolase B. | 0.990 |
| ALDOA | ALDOC | ENSPPYP00000024596 | ENSPPYP00000009108 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. | 0.992 |
| ALDOA | GCK | ENSPPYP00000024596 | ENSPPYP00000019722 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Phosphotransferase. | 0.835 |
| ALDOA | GPI | ENSPPYP00000024596 | ENSPPYP00000011012 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). | 0.952 |
| ALDOA | HK1 | ENSPPYP00000024596 | ENSPPYP00000002765 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] | 0.911 |
| ALDOA | HK2 | ENSPPYP00000024596 | ENSPPYP00000013670 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | HK2 isoform 1. | 0.877 |
| ALDOA | HK3 | ENSPPYP00000024596 | ENSPPYP00000017995 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | HK3 isoform 2. | 0.843 |
| ALDOA | HKDC1 | ENSPPYP00000024596 | ENSPPYP00000002767 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Hexokinase domain containing 1. | 0.852 |
| ALDOA | PGM2 | ENSPPYP00000024596 | ENSPPYP00000016381 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Phosphoglucomutase-2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5- phosphopentoses. May also catalyze the interconversion of glucose-1- phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity (By similarity). | 0.823 |
